Vol 13, No 4 (2025)
- Year: 2025
- Articles: 10
- URL: https://ogarev-online.ru/turner/issue/view/25663
- DOI: https://doi.org/10.17816/PTORS.134
Clinical studies
Impact of surgical correction of severe scoliotic spinal deformities on sagittal balance parameters in adolescents
Abstract
BACKGROUND: Surgical correction of scoliotic spinal deformities involving long-segment spinal fusion inevitably leads to changes in sagittal balance parameters, which may affect treatment outcomes in patients with scoliosis. This issue has been addressed only sporadically in the scientific data and requires further investigation.
AIM: This study aimed to analyze the impact of spinal deformity surgical correction on sagittal balance parameters in adolescents with severe thoracic idiopathic scoliosis in the early postoperative period.
METHODS: The study included 38 patients who underwent surgery between 2021 and 2025, which consisted of discectomy–apophysectomy at the apex of the main scoliotic curve, intraoperative halo traction, and correction and stabilization of the deformity using a posterior multisegmental pedicle screw instrumentation in a single surgical session. The inclusion criteria were as follows: idiopathic scoliosis with a primary thoracic curve; age 12–17 years; availability of standing full-spine radiographs in two projections obtained before and after surgery; and main scoliotic curve with a Cobb angle of more than 80°. The non-inclusion criteria included: congenital spinal, spinal canal, or spinal cord abnormalities; systemic musculoskeletal disorders; lower limb orthopedic condition; previous surgery on the spine, pelvic ring, or chest; poor-quality radiographs precluding reliable sagittal balance assessment; and refusal to participate in the study. Radiographic examination was performed preoperatively and 10–14 days after surgery. The regional and global sagittal balance parameters and frontal plane deformity characteristics were assessed.
RESULTS: Deviations in global sagittal balance parameters (SSA, TPA, and SVA) were observed preoperatively in 11 of 38 patients (28.9%). After surgery, such deviations were observed in 2 patients (5.3%). Insufficient correction of the kyphotic component of the deformity was identified as a significant risk factor for the persistence of anterior sagittal imbalance after surgery in patients with severe idiopathic scoliosis.
CONCLUSION: Surgery using the described approach achieves optimal global and regional sagittal balance parameters in most adolescents with severe idiopathic scoliosis. However, in cases of extremely severe deformities (Cobb angle >120–130°), which are characterized by a pronounced kyphotic component, techniques enabling greater correction of thoracic kyphosis should be considered.
355-363
Pulmonary function in patients with congenital pectus excavatum
Abstract
BACKGROUND: Pectus excavatum is the most common congenital chest wall deformity. To date, there is no consensus on whether this deformity interferes with normal lung growth.
AIM: This study work aimed to evaluate the effect of age at clinical onset of pectus excavatum on pulmonary function.
METHODS: A comparative analysis of pulmonary function was performed in 38 patients with pectus excavatum before thoracoplasty according to the Nuss procedure and before removal of the chest wall fixation bar. The inclusion criteria were congenital chest wall deformity, a Haller index greater than 3.25, a compression index less than 0.89, and age 9–15 years at the time of the Nuss procedure. The non-inclusion criteria were scoliosis greater than grade III, congenital heart defects, recurrence of chest wall deformity, verified genetic or systemic diseases, and refusal of the patient or legal representative to participate in the study. The patients were divided into two groups. Group 1 included all patients with pectus excavatum aged 9–11 years who underwent evaluation and surgery during the study. Group 2 included a stratified sample of 19 patients with the same deformity aged 12–15 years.
RESULTS: Before thoracoplasty, group 2 demonstrated lower vital capacity than group 1 (p = 0.037). The ratio of forced expiratory volume in 1 second to forced vital capacity was also lower in group 2 (p = 0.079), as was the mean forced expiratory flow between 25% and 75% of forced vital capacity (p = 0.027). No significant differences in pulmonary function parameters were identified between the two groups before removal of the chest wall fixation bar. Significant differences in pulmonary function parameters were also observed between measurements obtained before thoracoplasty and before chest wall fixation bar removal in both groups.
CONCLUSION: The identified statistically significant differences in pulmonary function parameters between age groups of patients with pectus excavatum before thoracoplasty suggest age-related deterioration of lung function in the absence of surgery. However, long-term prospective studies in patients from childhood through adolescence are required to confirm this assumption.
364-374
Analysis of the causes of unfavorable outcomes of functional treatment for infants with developmental hip dislocation
Abstract
BACKGROUND: The functional method is currently considered an effective treatment approach for children with developmental hip dislocation. This method involves the gradual centering of the femoral head within the acetabulum and fixation of the lower extremities using an orthosis with preserving motion in the hip and knee joints. However, complications may occur, including postreduction avascular necrosis of the femoral head and joint instability. These complications contribute to severe irreversible changes, early development of dysplastic coxarthrosis, and patient disability. The analysis of the factors leading to these adverse outcomes may improve treatment effectiveness; however, these issues remain understudied.
AIM: This study aimed to identify and analyze the main causes of unfavorable outcomes of functional treatment for dislocated developmental dysplasia of the hip in infants.
METHODS: The study was based on the examination of 56 children aged 1 to 3 years with a history of developmental hip dislocation who had received outpatient functional treatment at their place of residence, as well as a questionnaire survey of their parents. Exclusion criteria were neurological disorders and teratogenic or pathological hip dislocations. The main group comprised 26 children with unfavorable treatment outcomes, whereas the control group comprised 30 children without complications. The survey was conducted using a specially developed questionnaire designed to assess the timeliness of diagnosis and quality of outpatient orthopedic care provided to the children. Statistical analysis of the collected data was performed.
RESULTS: The main causes of treatment failure at the outpatient stage of orthopedic care were noncompliance with orthosis use by parents, prolonged disregard of the child’s anxiety during treatment, incomplete adherence to medical recommendations, and delayed attendance at scheduled follow-up visits with an orthopedic specialist.
CONCLUSION: The development of complications during functional treatment of children with developmental hip dislocation largely depends on social factors. These factors may be considered by outpatient orthopedic specialists to reduce the incidence of complications and, in most cases, help prevent the need for surgery.
375-383
Comparative characteristics of vertical body balance in children with different body types and pectus excavatum before and after surgery
Abstract
BACKGROUND: To achieve a comprehensive understanding of the multilevel mechanisms underlying organ and system function in children with pectus excavatum, thoracic biomechanics and whole-body biomechanics have been increasingly studied. This enables clinicians to gain a clearer understanding of the full diversity of adaptive responses of the patient’s body to deformity surgery.
AIM: This study aimed to evaluate changes in postural responses in children with asymmetric pectus excavatum during different stages of postoperative rehabilitation, depending on body mass index.
METHODS: Two groups of patients of both sexes aged 13–16 years with severe left-sided pectus excavatum underwent clinical, radiological, and stabilometric assessments. The first group consisted of 18 patients with an asthenic body type and a body mass index below 18.50 kg/m2. The second group comprised 15 normosthenic patients with a body mass index greater than 18.50 kg/m2 and less than 24.99 kg/m2. The exclusion criteria were as follows: overweight children; patients with right-sided or symmetric pectus excavatum; and those with other concomitant chest and thoracolumbar deformities and anomalies. All patients underwent minimally invasive reconstructive surgery to correct anterior chest wall deformity. The parameters of the whole-body center of pressure displacement and contralateral foot pressure centers were analyzed preoperatively and postoperatively (mean follow-up, 2 years). The results were compared with data from 20 healthy age-matched children with normal body mass index.
RESULTS: Preoperative stabilometric parameters indicated impaired vertical balance in both groups, with more pronounced disturbances in patients with asthenia. In all patients, compression of the pericardium by the deformed sternum was assumed to alter the characteristics of neural signals originating from its proprioceptors, thereby inducing changes in the postural control system. In addition, differences in postural strategies were identified between the patient groups, which presumably affected the stability of their vertical balance. After corrective surgery, normosthenic patients demonstrated greater improvement in vertical body balance compared with patients with asthenia. The achieved balance function was 83% and 78%, respectively (p = 0.047), which may be explained by variability in the adaptive capacity of the postural control system in patients with different body mass indexes. Following relief of pericardial compression, changes in the spectrum of proprioceptive signals in normosthenic patients may have led to more adequate postural system responses compared with asthenic patients.
CONCLUSION: Patients with pectus excavatum and low body mass index require a personalized rehabilitation strategy after minimally invasive surgery for deformity correction. This approach is intended to facilitate postoperative recovery in children and promote normalization of their postural balance.
384-397
Experimental and theoretical research
Effect of diastasis shape and size during calcaneal lengthening osteotomy on correction outcomes in different forms of flatfoot: an experimental cadaveric study
Abstract
BACKGROUND: Despite the high prevalence of flatfoot in children, the development of surgical techniques for its treatment has significantly outpaced their biomechanical justification. Cadaveric studies in traumatology and orthopedics have traditionally served as a primary method for gaining deeper insight into the biomechanics of deformities. Preoperative planning of osteotomy gap parameters remains a relevant issue when correcting various clinical forms of pediatric flatfoot.
AIM: This study aimed to evaluate the effect of the shape and size of the osteotomy gap, specifically its angular and linear parameters, on the correction of different clinical forms of flatfoot during calcaneal lengthening osteotomy under controlled conditions (in a cadaveric study).
METHODS: An experimental cadaveric study was conducted using a vertical load simulation device with radiographic control. The study was performed on 8 anatomical specimens of the lower leg and foot. The study consisted of two stages. During the first stage, anatomical specimens were prepared for placement in the vertical load simulation device, followed by radiographic examination under unloaded conditions and a simulated load of 750 N. During the second stage, a cadaveric flatfoot model was created with the possibility of simulating two clinical forms (abducted planovalgus deformity and flatfoot deformity), followed by calcaneal osteotomy and sequential implantation of specially designed implants of various shapes under radiographic control. Radiographic parameters were assessed at each stage of the study, including the Kite angle, talonavicular coverage angle (according to V. Mosca), cuboid abduction angle, longitudinal arch angle, calcaneal inclination angle, and Meary angle.
RESULTS: At the first stage of the study with anatomical specimens, reproducible cadaveric flatfoot models were successfully obtained using the proposed method, allowing the simulation of two clinical forms: abducted planovalgus deformity and flatfoot deformity. At the second stage, calcaneal lengthening osteotomy performed with different implant shapes demonstrated distinct patterns of change in radiographic parameters depending on the clinical form of flatfoot, which reflects differences in correction biomechanics.
CONCLUSION: The study demonstrated that the shape of the osteotomy gap, when selected in accordance with the clinical form of flatfoot, may play a key role in restoring the proper foot configuration.
398-409
Effect of cell-seeded polycaprolactone-based implants on regenerative processes in a jaw bone defect in rabbits
Abstract
BACKGROUND: In modern regenerative medicine, the development of personalized biomedical cellular products for the replacement of bone tissue defects is crucial. Such products consist of a cellular component, a scaffold designed to retain cells and provide mechanical support, and auxiliary components. In vitro experiments do not adequately assess the effects of these constructs on bone regeneration or on the systemic response of the recipient organism.
AIM: This study aimed to determine the outcomes of implanting scaffolds based on polycaprolactone, hydroxyapatite, and dental pulp stem cells into jaw bone defects in rabbits.
METHODS: The study was conducted in Soviet (Russian) Chinchilla rabbits (n = 10) weighing 3.5–4.5 kg and aged 1–1.5 years bred under vivarium conditions. Four teeth were extracted from each animal (40 teeth in total), then the animals were divided into 5 groups. The regenerative outcomes were assessed after 4 months. To evaluate differences in the extent and rate of defect healing, histopathological examination of the implantation sites was performed. The degree of fibrosis, inflammation, and bone tissue remodeling was assessed in hematoxylin and eosin–stained sections, whereas the distribution pattern of implanted cells labeled with iron oxide nanoparticles was evaluated using Perls’ staining.
RESULTS: At the implantation sites, scaffolds (both cell-seeded and cell-free) accelerated bone defect remodeling and fibrosis without the formation of coarse scar tissue. The most favorable combination of outcomes—namely minimal inflammation, the most advanced stage of bone tissue remodeling, and mature connective tissue formation at the implantation site—was observed in the group receiving copper-coated polycaprolactone scaffolds seeded with dental pulp stem cells.
CONCLUSION: The results confirm the promise of this approach for the development of bioengineered constructs for the reconstruction of bone defects.
410-429
Clinical cases
Surgery in a 7-year-old child with blast injury to the left shoulder and left gluteal region with penetrating abdominal trauma
Abstract
The management of pediatric patients with gunshot-related polytrauma remains a major challenge, both in the acute phase due to the combined nature of injuries, and during reconstructive surgery. Treatment outcomes depend on an appropriately selected management strategy from the moment of first aid through specialized surgical rehabilitation at a tertiary care center. This clinical case report presents the management of a 7-year-old girl with combined blast injuries to the left shoulder and left gluteal region. During the clinical course, a foreign body migrated from the gluteal region into the abdominal cavity. The injury resulted from an explosive device detonating in proximity to the child. The patient was initially admitted to a primary care hospital in Krasnyi Lyman due to a combined blast injury. Primary surgical debridement of the left shoulder wound was performed with primary wound closure and immobilization using a plaster splint. After stabilization, the child was transferred to the Central District Multidisciplinary Hospital in Svatove, where revision and gauze tamponade of the left gluteal wound were performed. Later that day, the patient was transferred to the Republican Children’s Clinical Hospital in Luhansk, where repeated surgical debridement of the left shoulder wound was carried out with removal of primary sutures and application of external fixation using a wire–rod external fixation device for an open fracture of the left humerus. An additional diagnostic evaluation revealed a foreign body in the soft tissues of the gluteal region. The child was transported by air medical service to the Research Institute of Emergency Pediatric Surgery and Traumatology (Dr. Roshal Clinic) in Moscow for further specialized treatment. The diagnosis of blast injury to the left shoulder and left gluteal region was confirmed in the Clinic, and the foreign body migration into the abdominal cavity was identified. An individualized, staged surgical treatment strategy was developed during the inpatient stay. The appropriately selected treatment strategy resulted in survival and function restoration of the injured organs and limb segments. Modern adjunctive physical wound treatment modalities ensured rapid wound preparation for closure without infectious complications.
430-439
Selective immunosuppressant tofacitinib in a child with multiple epiphyseal dysplasia associated with osteoarthritic changes: a case report
Abstract
Multiple epiphyseal dysplasia is a group of musculoskeletal disorders characterized by genetic heterogeneity in both inheritance patterns and clinical manifestations. One of the most frequent and unfavorable outcomes of this dysplasia is hip osteoarthritis with displacement of the femoral head. Clinical and instrumental manifestations of osteoarthritis in children with multiple epiphyseal dysplasia may often mimic juvenile idiopathic arthritis. Nonsteroidal anti-inflammatory drugs are considered to be pathogenetically justified; however, their efficacy is not always sufficient. The impact of immunosuppressive therapy on the course of osteoarthritis in children with multiple epiphyseal dysplasia has not been previously studied. This article presents a clinical case of successful use of the anti-inflammatory drug tofacitinib, a selective immunosuppressant, in an 11-year-old child with type 4 multiple epiphyseal dysplasia. The disease course was complicated by osteoarthritis and displacement of the right femoral head. No evidence supporting juvenile idiopathic arthritis was identified. Long-term therapy with nonsteroidal anti-inflammatory drugs failed to produce the desired effect. In combination with mechanotherapy, tofacitinib (a Janus kinase inhibitor) 10 mg/day in two divided doses resulted in the resolution of osteoarthritic manifestations and prevention of progression of femoral head displacement. Janus kinase inhibitors are well-known as targeted synthetic disease-modifying antirheumatic drugs. These inhibitors are comparable in efficacy to traditional genetically engineered biological agents used to treat juvenile idiopathic arthritis. Their mechanism of action is based on selective inhibition of intracellular signaling pathways of proinflammatory cytokines. The experience of using selective Janus kinase inhibitors in rheumatology may justify their application in children with skeletal dysplasias complicated by osteoarthritic changes. Type 4 multiple epiphyseal dysplasia is a skeletal dysplasia that inevitably leads to hip osteoarthritis and femoral head displacement. The use of Janus kinase inhibitors in children with this dysplasia accompanied by osteoarthritic manifestations may therefore be justified and highly promising.
440-451
Scientific reviews
Role of Intranatal cervical spine injury in the pathogenesis of idiopathic scoliosis: integration of neurological and biomechanical aspects. A review
Abstract
Idiopathic scoliosis remains one of the most common and complex orthopedic disorders in children and adolescents. Despite recognition of the role of genetic, hormonal, and environmental factors, the initial trigger initiating spinal deformity at an early age remains a subject of debate. This review analyzes the international scientific data addressing intranatal cervical spine injury as a potential provoking factor in the development of idiopathic scoliosis in genetically predisposed individuals. A systematic analysis of publications indexed in PubMed, Google Scholar, eLibrary, and CyberLeninka from 2010 to 2024 was conducted, addressing the etiology of idiopathic scoliosis, with an emphasis on studies examining the association between complicated childbirth, cervical spine biomechanics, and the subsequent development of spinal deformity. This review summarizes and analyzes current evidence on the potential role of intranatal injury to the craniovertebral junction in the pathogenesis of idiopathic scoliosis, integrating neurological, biomechanical, and genetic aspects. It has been demonstrated that mechanical stress applied to the cervical spine during childbirth (including breech presentation, precipitous or prolonged labor, and the use of obstetric maneuvers) may result in microinjury to dural structures, brainstem ischemia, and dysfunction of reticulospinal pathways. These alterations may lead to asymmetrical muscle tone, which, in pubertal growth acceleration and genetic susceptibility, manifests as a persistent three-dimensional spinal deformity. An integrative model of the pathogenetic cascade is proposed to explain the latent period and subsequent progression of idiopathic scoliosis. Intranatal cervical spine injury represents a considerable, although not exclusive, trigger in the development of idiopathic scoliosis. A comprehensive approach incorporating perinatal history assessment, early genetic screening, and ultrasound monitoring of the craniovertebral region in at-risk children may serve as a basis for developing primary prevention strategies for idiopathic scoliosis.
452-464
Obituaries
Nikolai G. Zhila (May 13, 1950 – December 13, 2025)
Abstract
Nikolai G. Zhila, a pediatric surgeon, traumatologist-orthopedist, and professor, passed away on December 13, 2025, after a prolonged illness. Dr. Zhila led an active professional life as a physician, surgeon, scientist, educator, and healthcare administrator. His career was closely associated with two regions at the eastern and western borders of Russia: the Far East, Khabarovsk Krai, and Saint Petersburg. Through all challenges of time, geography, and health, Dr. Zhila remained devoted to his life’s work until his final days.
465-467
