Vol 8, No 1 (2025)

the aim of this study was to evaluate the relationship between oculomotor synergies and brain oxygen status in mild traumatic brain injury (mTBI) using a simultaneous comparison of eye tracking (ET) and cerebral oxygenation parameters. Materials and methods. This non-randomized, single-center prospective study included 77 patients with mTBI (mean age 36.3 ± 4.8 years, 48 men, 29 women, median Glasgow Coma Scale 13.7 ± 0.7). Cerebral oximetry was used to determine the oxygen saturation level (SctO2) in the frontal lobe pole region (FLP). Eye movements were measured simultaneously using EyeTracker. The calculated parameters were: vertical and horizontal angular velocity of the eyeball (VA); left vertical angular velocity (LVAV); right vertical angular velocity (RVAV); left horizontal angular velocity (LHAV); and right horizontal angular velocity (RHAV). The vertical and horizontal ocular vergence reactivity index (VRx) were calculated as the Pearson’s correlation coefficient between the corresponding angular velocities of the right and left eyes. Significance was preset at p < 0.05. Results. SctO2 in FLP ranged from 62% to 79. The mean SctO2 values were 69.26 ± 6.96% compared to the left FLP and 70.25 ± 7.58% compared to the right FLP (p = 0.40). Overall analysis of the eye tracking data revealed the following eye tracking parameter values: LVAV 0.327 ± 0.263 rad/sec; LHAV 0.201 ± 0.164 rad/sec; RVAV 0.361±0.269 rad/sec; and RHAV 0.197±0.124 rad/sec. The estimated vertical vergence reactivity index (VVx) was 0.80±0.12. The estimated horizontal vergence reactivity index (HVx) was 0.82±0.11. VVx and HVx correlated with SctO2 levels in the corresponding LPD (p=0.038; r=0.235; p=0.048; r=0.218, respectively, p=0.035; r=0.241; p=0.039; r=0.235, respectively). Conclusions. VVx and HVx correlate with SctO2 level in FLP (p<0.01) in mTBI. No significant correlation was found between SctO2 levels and vertical and horizontal angular velocities of the eyeballs. ET may help to quantify the severity of ocular movement disturbances after mTBI and to study the contribution of cerebral oxygenation impairment to this process.

chronic inflammatory periodontal diseases, particularly in patients with autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus, lead to progressive tissue destruction and reduced quality of life. The primary aim of this study was to evaluate the efficacy of low-dose corticosteroids in the regeneration of periodontal tissues in such patients. This double-blind, randomized controlled clinical trial included patients with autoimmune conditions and moderate to severe periodontitis. The test group received low doses of prednisolone (5 mg) combined with standard periodontal therapy, while the control group received a placebo. Outcomes were assessed through clinical, biochemical, and immunohistochemical methods, including radiography and patient-reported surveys. Results indicated a significant reduction in pocket depth and inflammatory markers in the test group, highlighting the anti-inflammatory effects of corticosteroids and improvements in bone tissue condition. Conclusions confirm that low-dose corticosteroids can be effectively applied in periodontal treatment for patients with autoimmune disorders, promoting tissue recovery and enhancing quality of life.

the acute phase response is an important mechanism in coronavirus disease (COVID-19). As part of this process, interleukin-6 stimulates hepatocytes to produce acute phase proteins such as CRP and ferritin. However, hyperferritinemia can also be caused by other mechanisms. In particular, cytolysis and systemic disorders of iron metabolism are important in COVID-19. An increase in aminotransferase levels is indicative of cytolysis. Therefore, a comparison of these parameters will facilitate the study and comparison of the dynamics of acute-phase response, cytolysis, and systemic iron metabolism disorders in patients with SARS-CoV-2 infection. Consequently, the analysis of these parameters will facilitate the study and comparison of the dynamics of acute phase response, cytolysis, and systemic iron metabolism disorders in patients with COVD-19. The objective of our study was to examine the dynamics of interleukin-6, C-reactive protein, ferritin, aspartate aminotransferase, and alanine aminotransferase in patients with moderate to severe COVID-19 that does not require anti-interleukin therapy. The study included 19 patients with COVID-19 who were treated with glucocorticoids and anticoagulants but not receiving any anticytokine therapy due to the nonsevere course of the disease. The five parameters above were studied on the first day of enrollment and by the end of the first week of treatment. Concentrations of interleukin-6 and C-reactive protein decreased markedly (by more than 90%, p<0,001) from the initial elevated levels during this period. In contrast, the levels of ferritin and aspartate aminotransferase remained unchanged, exhibiting a tendency to increase. Concurrently, alanine aminotransferase levels exhibited a notable surge of 224,2% (p=0,003). Consequently, the dynamics of the acute-phase response did not align with the changes in cytolysis and iron metabolism imbalance indices. Meanwhile, the latter two processes contribute to the complications of the infection, including long COVID. Further investigation is necessary to elucidate the mechanisms and adverse outcomes associated with these phenomena.

zopiclone is an agonist of benzodiazepine receptors of the non-benzodiazepine series, is the first hypnotic cyclopyrrolone. With prolonged use, drug dependence and addiction develop, as well as zopiclone is used for non-medical purposes, therefore it is the object of forensic chemical and chemical toxicological research. The therapeutic dose of zopiclone with oral administration is 3.75-15.0 mg, the toxic dose is 15-90 mg, and the lethal dose is ? 90 mg. In case of fatal poisoning with zopiclone, concentrations in biological objects will be in the blood ? 0.62 mg/l; urine ? 10.5 mg/l; brain ? 2.8 mg/kg; heart ? 1.6 mg/kg; kidneys ? 1.7 mg/kg; muscles ? 1.9 mg/kg; in liver tissue ? 4.9 mg/kg.

the relevance and importance of professional creative thinking in modern society is considered. The following paradigms served as methodological foundations for the organization of research: procedural and activity-based; differentiated development of components of professional creative thinking, structural and dynamic; integrated approach in the organization of research. The levels of professional creative thinking, the main types of thinking, emotional states that stimulate the manifestation (implementation) of professional creative thinking, the disadvantages of the existing theory of professional creative thinking, and the ways of optimization in the existing (implemented in society) theory of professional creative thinking are considered.

the question of creativity attracts significant attention from researchers in the field of psychology. Modern understanding of the essence of creativity is related to thinking, motivation, and personality factors. Depending on these factors, individuals may exhibit various forms of creative strategies. One such factor is introversion-extraversion, which regulates the modes of creative exploration. The issue of creativity is particularly pronounced in the arts, where introversion-extraversion can play an important role in the creation of artistic works. Our study is aimed at exploring the relationship between creativity and introversion-extraversion among artists. Using E.P. Torrance's tests of creative thinking and G.Yu. Eysenck's psychological type assessment, we identified a correlation between creativity and introversion-extraversion in artists. We distinguished three groups of artists: deep introverts, moderate introverts, and extraverts. Using the Kruskal-Wallis test, we found that the highest level of creativity is observed in artists with a moderate level of introversion.

from a physiological point of view, surgical operations cause patients to experience multicomponent stress, as the functions of vital systems and organs are disrupted in humans. Being in bed rest during the postoperative period, patients are in a state of hypokinesia, that is, reduced motor activity. That is why in modern science it is considered relevant to manage patients after surgery as part of rehabilitation measures. Various rehabilitation techniques are actively used for rehabilitation within the framework of abdominal rehabilitation, which will be discussed in this article. Initially, the author of the article investigated the concept of neuroabdominal recovery. Further in the article, the features of the abdominal recovery technique were studied by D.R. Yagudin. Then the author considered and defined the role of visceral (abdominal) massage as a technique of neuroabdominal recovery. Based on the theoretical analysis, the author of the article has developed a model of neuroabdominal recovery of patients. Based on the conducted research, D.R. Yagudin suggests the following definition of patients' neuroabdominal recovery. Neuroabdominal recovery should be understood as a method of rehabilitation measures for the patient, which involves the integrated use of recovery tools: medications, neurobiological rehabilitation tools, as well as the use of visceral (abdominal) abdominal massage.

the problem of the use of violent methods by parents towards a child is relevant and important in the policy of forming a healthy family today. The relevance of this area is actively being developed at the level of state policy. On March 18, 2021, the Government of the Russian Federation issued an order to extend the National Strategy for Children 2012-2017 until 2025 inclusive. We examined 103 families living in the Republic of Sakha (Yakutia), diagnosed and analyzed the methods of violent upbringing towards a child.

anxiety affects both the generation of children and the adult population. To find out how stressful situations can have devastating effects on the human brain, researchers continue to analyze at all age stages. At the present stage of development, the destructive effect of stress on the brain of the adult generation is clearly visible. The brain condition of a young child is no exception in this regard. In fact, many scientists agree that the stressful situation and anxiety experienced by a young child negatively affects his future life. The constant negative stress that surrounds a young child leads to irreversible damage to the child's brain. The younger generation is the most sensitive part of society. In this regard, it is the child who becomes most sensitive to various negative manifestations. As a result of numerous experimental studies, it has been revealed that the most common manifestation in children is an increase in anxiety and fear. And this determines the urgency of the issue of anxiety among the younger generation.

the article is devoted to the current problem of the influence of the unconscious on consciousness. Our unconscious part of the brain contains hundreds of times more information than the conscious component. Consciousness is a reflection of the objective material world in the human mind and the sum of various psychological processes. Consciousness and subconsciousness are two aspects of the unity of opposites that make up the psychological whole of a person. Consciousness is based on the existence of the subconscious and is its condition. The subconscious dominates and is limited by consciousness. Consciousness is the highest regulator of the subconscious and even of all psychological activity. Consciousness and subconsciousness influence each other and depend on each other, and are also transformed into each other under certain conditions. Consciousness has functional characteristics such as cognition, experience, purpose, control, thinking and creativity. It is the sum of all conscious psychological actions. The forms of consciousness are reason, logic, paradigm, judgment, reasoning, conscience and moral sense. Understanding the functional characteristics and forms of consciousness activity, it is easy to see that consciousness is the source of individual thoughts and power. The subconscious has such functional characteristics as cognition, experience, storage, learning, creation. It is the sum of all psychological actions that people do not know about. The forms of subconscious activity are intuition, emotion, conviction, encouragement, suggestion, imagination, general system, memory and creativity. The subconscious is not limited by time and space. It contains innate instincts, past feelings and wisdom of a person, present consciousness and knowledge, as well as thoughts and insights about the future and has enormous possibilities of transmission and reception. In this direction, it is necessary to work on the subconscious in order to form the necessary directions of consciousness.

this article is devoted to a topic that has been of interest to linguists for a very long time, has been comprehensively studied and is constantly being revealed from new, sometimes unexpected sides – the study of written information, in particular, textual information. I see several main questions related to this topic, namely: How can I get information from the text, how much of this information can I get and what will the information give me, or how and where can I use this information. But most of all, as a researcher, I am interested in the issue of obtaining information that is not on the surface. The novelty of my research lies in the approach to text analysis, it consists in the application of psycholinguistic methods. While reviewing various sources of information, I have not found any scientific articles containing an experiment on the analysis of written texts using psycholinguistics methods. In particular, the analysis of texts related to journalistic style. Thus, this article is an alternative view of obtaining information from texts, an attempt to extract from them the data that cannot be obtained using all the methods that have been used so far. This is a test of how much information can be hidden from a researcher relying on already known methods, as well as the possible application of new data obtained by experimental methods.

it seems that today very few people have not encountered such a disease as coronavirus. Everyone who has had it is well aware of the numerous symptoms, including fever, cough and runny nose, difficulty breathing, loss of sense of smell. But it is important to understand that these signs of the disease are in many ways only the tip of the iceberg. The infection affects the neurological and mental state of patients. Approximately 30% of those who have recovered have long-term complications such as increased anxiety, depression, memory loss, and panic attacks. The purpose of this study is to analyze the impact of coronavirus infection on the human psyche.

the article examines the main aspects of the value-semantic sphere of the individual, psychological and social factors influencing the process of value formation, such as age, cultural background, family, religion and society as a whole. Various theoretical approaches to understanding values are described, including their definitions, classifications and relationship with the meaning of life. The influence of values and life meanings on behavior, attitude to life and the ability to adapt to difficult situations is analyzed, how values become an important support for individuals under stress and uncertainty, providing them with guidelines for decision-making and overcoming obstacles. Under stress and uncertainty, values become an important support, providing individuals with guidelines for decision-making and overcoming obstacles. The mechanisms of value formation in individuals during socialization are considered, including the stages of their formation, transformation and stabilization.

consideration of the organization of human cognition of the surrounding world through the analysis of such cognitive processes as sensation, perception, memory, attention, thinking, speech at the present stage of development of psychological science does not seem accurate enough. This article presents a model for organizing the process of human cognition of the surrounding world from a post-non-classical position. The basis of cognitive activity is a sensory reflection of the surrounding reality (emotions and perception). Attention and speech are tools of cognition that increase the efficiency of cognitive activity. Attention is considered as the direction of sensory systems into an area of interest in the surrounding world that is subject to cognition. And speech becomes a tool for structuring the process of cognition. Thanks to speech, sensory reflection becomes abstract, devoid of the attributes of sensuality, and human thinking is born. Memory is not strictly a mental process. Memory is considered as a general property of matter. This model of the organization of cognitive activity allows us to systematically approach the development of empirical research programs in this area, as well as the organization of teaching topics related to the process of cognition within the framework of general psychology for psychological areas.

visual art plays a crucial role in the comprehension and representation of traumatic experiences, providing a space for their processing and transformation. However, the process of artistic representation of trauma faces several challenges: resistance to symbolization, the risk of retraumatization, and the influence of cultural context. This article explores the mechanisms of trauma representation in visual art, analyzing its role in capturing and reinterpreting traumatic experiences, as well as examining ways to break the cycle of traumatic representation. The theoretical and practical aspects discussed in the article offer a deeper understanding of how art facilitates the departure from repetitive patterns of traumatic experience and how artistic representation can contribute to the processes of comprehension and transformation of trauma.