Мақаланы E-mail арқылы жіберу HPLC-MS Method for Simultaneous Quantitative Determination of an Innovative Russian Gestagen and its Metabolites in Rat and Rabbit Blood Sera
- Авторлар: Stepanova E.S.1, Makarenkova L.M.1, Chistyakov V.V.1, Rybakov Y.L.2, Gukasov V.M.2, Fedotcheva T.A.3,4, Parshin V.A.3, Votyakov V.A.3, Shimanovskii N.L.3
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Мекемелер:
- People’s Friendship University of Russia (RUDN University)
- Scientific Research Institute Federal Research Centre for Project Evaluation and Consulting Services
- N. I. Pirogov Russian National Research Medical University, Ministry of Health of the RF
- All-Russia Research Institute of Medicinal and Aromatic Plants (VILAR), Russian Academy of Agricultural Sciences
- Шығарылым: Том 52, № 12 (2019)
- Беттер: 1016-1020
- Бөлім: Structure of Chemical Compounds, Methods of Analysis and Process Control
- URL: https://ogarev-online.ru/0091-150X/article/view/245584
- DOI: https://doi.org/10.1007/s11094-019-01944-x
- ID: 245584
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Тек жазылушылар үшін
Аннотация
An HPLC-MS method for simultaneous quantitative determination of a novel gestagenic pharmaceutical and two of its metabolites in rat and rabbit blood sera was developed and validated. The method was selective and specific. The detection limit for all analytes was 5 ng/mL; lower limit of quantitation, 10 ng/mL. Calibration curves for all analytes had the form y = ax + b. The correlation coefficients were >0.99. Matrix effects, degree of extraction, and stability of analytes in standard solutions, analytical samples, and the biomatrix with multiple freeze—thaw cycles were studied.
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Авторлар туралы
E. Stepanova
People’s Friendship University of Russia (RUDN University)
Хат алмасуға жауапты Автор.
Email: stepanova25@inbox.ru
Ресей, Moscow, 117198
L. Makarenkova
People’s Friendship University of Russia (RUDN University)
Email: stepanova25@inbox.ru
Ресей, Moscow, 117198
V. Chistyakov
People’s Friendship University of Russia (RUDN University)
Email: stepanova25@inbox.ru
Ресей, Moscow, 117198
Yu. Rybakov
Scientific Research Institute Federal Research Centre for Project Evaluation and Consulting Services
Email: stepanova25@inbox.ru
Ресей, Moscow, 123995
V. Gukasov
Scientific Research Institute Federal Research Centre for Project Evaluation and Consulting Services
Email: stepanova25@inbox.ru
Ресей, Moscow, 123995
T. Fedotcheva
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the RF; All-Russia Research Institute of Medicinal and Aromatic Plants (VILAR), Russian Academy of Agricultural Sciences
Email: stepanova25@inbox.ru
Ресей, Moscow, 117997; Moscow, 113628
V. Parshin
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the RF
Email: stepanova25@inbox.ru
Ресей, Moscow, 117997
V. Votyakov
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the RF
Email: stepanova25@inbox.ru
Ресей, Moscow, 117997
N. Shimanovskii
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the RF
Email: stepanova25@inbox.ru
Ресей, Moscow, 117997
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