电邮这篇文章 HPLC-MS Method for Simultaneous Quantitative Determination of an Innovative Russian Gestagen and its Metabolites in Rat and Rabbit Blood Sera
- 作者: Stepanova E.S.1, Makarenkova L.M.1, Chistyakov V.V.1, Rybakov Y.L.2, Gukasov V.M.2, Fedotcheva T.A.3,4, Parshin V.A.3, Votyakov V.A.3, Shimanovskii N.L.3
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隶属关系:
- People’s Friendship University of Russia (RUDN University)
- Scientific Research Institute Federal Research Centre for Project Evaluation and Consulting Services
- N. I. Pirogov Russian National Research Medical University, Ministry of Health of the RF
- All-Russia Research Institute of Medicinal and Aromatic Plants (VILAR), Russian Academy of Agricultural Sciences
- 期: 卷 52, 编号 12 (2019)
- 页面: 1016-1020
- 栏目: Structure of Chemical Compounds, Methods of Analysis and Process Control
- URL: https://ogarev-online.ru/0091-150X/article/view/245584
- DOI: https://doi.org/10.1007/s11094-019-01944-x
- ID: 245584
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详细
An HPLC-MS method for simultaneous quantitative determination of a novel gestagenic pharmaceutical and two of its metabolites in rat and rabbit blood sera was developed and validated. The method was selective and specific. The detection limit for all analytes was 5 ng/mL; lower limit of quantitation, 10 ng/mL. Calibration curves for all analytes had the form y = ax + b. The correlation coefficients were >0.99. Matrix effects, degree of extraction, and stability of analytes in standard solutions, analytical samples, and the biomatrix with multiple freeze—thaw cycles were studied.
作者简介
E. Stepanova
People’s Friendship University of Russia (RUDN University)
编辑信件的主要联系方式.
Email: stepanova25@inbox.ru
俄罗斯联邦, Moscow, 117198
L. Makarenkova
People’s Friendship University of Russia (RUDN University)
Email: stepanova25@inbox.ru
俄罗斯联邦, Moscow, 117198
V. Chistyakov
People’s Friendship University of Russia (RUDN University)
Email: stepanova25@inbox.ru
俄罗斯联邦, Moscow, 117198
Yu. Rybakov
Scientific Research Institute Federal Research Centre for Project Evaluation and Consulting Services
Email: stepanova25@inbox.ru
俄罗斯联邦, Moscow, 123995
V. Gukasov
Scientific Research Institute Federal Research Centre for Project Evaluation and Consulting Services
Email: stepanova25@inbox.ru
俄罗斯联邦, Moscow, 123995
T. Fedotcheva
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the RF; All-Russia Research Institute of Medicinal and Aromatic Plants (VILAR), Russian Academy of Agricultural Sciences
Email: stepanova25@inbox.ru
俄罗斯联邦, Moscow, 117997; Moscow, 113628
V. Parshin
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the RF
Email: stepanova25@inbox.ru
俄罗斯联邦, Moscow, 117997
V. Votyakov
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the RF
Email: stepanova25@inbox.ru
俄罗斯联邦, Moscow, 117997
N. Shimanovskii
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the RF
Email: stepanova25@inbox.ru
俄罗斯联邦, Moscow, 117997
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