Email this article Comparison of Quantitative Analytical Techniques for Dabigatran in Blood Plasma of Humans with Knee Replacements
- Authors: Kozlov A.V.1, Smirnov V.V.1, Sychev D.A.2, Bochkov P.O.3, Chistyakov V.V.4, Stepanova E.S.4, Makarenkova L.M.4
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Affiliations:
- I. M. Sechenov First Moscow State Medical University (Sechenov University)
- Russian Medical Academy of Continuous Professional Education, Ministry of Health of the RF
- V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
- Research and Education Center, Peoples’ Friendship University of Russia
- Issue: Vol 53, No 8 (2019)
- Pages: 771-774
- Section: Article
- URL: https://ogarev-online.ru/0091-150X/article/view/245993
- DOI: https://doi.org/10.1007/s11094-019-02077-x
- ID: 245993
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Abstract
Two different literature methods were used to compare the experimental efficacy and accuracy of dabigatran assays in blood of 30 patients with knee replacements. Blood plasma was collected from patients who underwent anticoagulant therapy and were administered the medicine at a dose of 220 mg. Residual and peak dabigatran concentrations were determined by HPLC-MS and HPLC-MS/MS.
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About the authors
A. V. Kozlov
I. M. Sechenov First Moscow State Medical University (Sechenov University)
Author for correspondence.
Email: aleksei.kozlov1993@yandex.ru
Russian Federation, Moscow, 119991
V. V. Smirnov
I. M. Sechenov First Moscow State Medical University (Sechenov University)
Email: aleksei.kozlov1993@yandex.ru
Russian Federation, Moscow, 119991
D. A. Sychev
Russian Medical Academy of Continuous Professional Education, Ministry of Health of the RF
Email: aleksei.kozlov1993@yandex.ru
Russian Federation, Moscow, 125993
P. O. Bochkov
V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Email: aleksei.kozlov1993@yandex.ru
Russian Federation, Moscow, 125315
V. V. Chistyakov
Research and Education Center, Peoples’ Friendship University of Russia
Email: aleksei.kozlov1993@yandex.ru
Russian Federation, Moscow, 117198
E. S. Stepanova
Research and Education Center, Peoples’ Friendship University of Russia
Email: aleksei.kozlov1993@yandex.ru
Russian Federation, Moscow, 117198
L. M. Makarenkova
Research and Education Center, Peoples’ Friendship University of Russia
Email: aleksei.kozlov1993@yandex.ru
Russian Federation, Moscow, 117198
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