Biochemical changes in rats after treatment with soft drink and menthol flavoured candy

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  • Authors: Isoje E.F.1, Okoro I.O.2, Ali B.M.3, Edo G.I.4, Yousif E.5, Okpoghono J.6, Okoro E.O.7, Okom S.U.1, Essaghah A.E.7, Umar H.8, Owheruo J.O.9, Akpoghelie P.O.9, Ahmed D.S.10
  • Affiliations:
    1. Department of Biochemistry, Faculty of Science, Delta State University of Science and Technology
    2. Department of Biochemistry, Faculty of Science, Delta State University
    3. Department of Air Conditioning Engineering, Faculty of Engineering, Warith Al-Anbiyaa University
    4. Department of Chemistry, Faculty of Science, Delta State University of Science and Technology
    5. Department of Chemistry, College of Sciences
    6. Department of Biochemistry, Faculty of Science, Delta State University of Science and Technology, Ozoro, Delta State, Nigeria 2 Department of Biochemistry, Faculty of Science, Delta State University
    7. Department of Medical Laboratory Science, Delta State University
    8. Operational Research Centre in Healthcare, Near East University
    9. Faculty of Science, Department of Food Science and Technology, Delta State University of Science and Technology
    10. Department of Chemical Industries, Institute of Technology-Baghdad, Middle Technical University
  • Issue: Vol 8, No 1 (2025)
  • Pages: 106-113
  • Section: Articles
  • URL: https://ogarev-online.ru/2618-9771/article/view/310382
  • DOI: https://doi.org/10.21323/2618-9771-2025-8-1-106-113
  • ID: 310382

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Abstract

The current study looked at the biochemical variations that occurred in rats after they were given menthol flavoured candies and soft drinks. Seventy male Wistar albino rats in total were acquired, split up into ten treatments of seven rats each, and treated with the following regimen for forty-two days. Group 1 is the control. Groups 2, 3, and 4 received 8, 5, and 2.5 ml of La Casera/kg body weight. Groups 5, 6, and 7 received 0.34, 0.22, and 0.11 g of Tom-Tom/kg body weight. The dosages for groups 8, 9, and 10 were 8, 5, and 2.5 ml of La Casera/kg body weight, as well as 0.34, 0.22, and 0.11 g of Tom-Tom/kg body weight correspondingly. The results showed that the groups given Tom-Tom and La Casera had lower levels of total protein (TP) and albumin (Alb), and significantly (p < 0.05) higher serum levels of alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), total cholesterol (T-Chol), triacylglycerol (TAG), and low-density lipoprotein cholesterol (LDL–C). Furthermore, there was a substantial (p < 0.05) increase in the serum levels of TP, Alb, and ALT between groups 7 and 5. Prolonged use of Tom-Tom mixed with La Casera should be avoided due to the detrimental alterations in biochemical parameters and subsequent health repercussions.

About the authors

E. F. Isoje

Department of Biochemistry, Faculty of Science, Delta State University of Science and Technology

Author for correspondence.
Email: arthuresa2006@gmail.com
Endurance F. Isoje is affiliated with the Department of Biochemistry at the Faculty of Science, Delta State University of Science and Technology, Ozoro, Delta State, Nigeria. P. M. B. 05, Ozoro-Kwale Road, Ozoro, Delta State

I. O. Okoro

Department of Biochemistry, Faculty of Science, Delta State University

Email: arthuresa2006@gmail.com
Department of Biochemistry, Faculty of Science, Delta State University. P.M.B. 1, Abraka, Delta State

B. M. A. Ali

Department of Air Conditioning Engineering, Faculty of Engineering, Warith Al-Anbiyaa University

Email: arthuresa2006@gmail.com
56001, Karbala

G. I. Edo

Department of Chemistry, Faculty of Science, Delta State University of Science and Technology

Email: arthuresa2006@gmail.com
G. I. Edo is affiliated with the Department of Chemistry, Faculty of Science, Delta State University of Science and Technology. P. M. B. 05, Ozoro-Kwale Road, Ozoro, Delta State

E. Yousif

Department of Chemistry, College of Sciences

Email: arthuresa2006@gmail.com
E. Yousif is affiliated with the Department of Chemistry, College of Sciences. Al Jadriyah Bridge, 64074, Baghdad

J. Okpoghono

Department of Biochemistry, Faculty of Science, Delta State University of Science and Technology, Ozoro, Delta State, Nigeria 2 Department of Biochemistry, Faculty of Science, Delta State University

Email: arthuresa2006@gmail.com
Department of Biochemistry, Faculty of Science, Delta State University of Science and Technology, Ozoro, Delta State, Nigeria. P. M. B. 05, Ozoro-Kwale Road, Ozoro, Delta State

E. O. Okoro

Department of Medical Laboratory Science, Delta State University

Email: arthuresa2006@gmail.com
Endurance F. Isoje is affiliated with the Department of Biochemistry, Faculty of Science, Delta State University of Science and Technology, Ozoro, Delta State, Nigeria. P.M.B. 1, Abraka, Delta State

S. U. Okom

Department of Biochemistry, Faculty of Science, Delta State University of Science and Technology

Email: arthuresa2006@gmail.com
Department of Biochemistry, Faculty of Science, Delta State University of Science and Technology P. M. B. 05, Ozoro-Kwale Road, Ozoro, Delta State

A. E. A. Essaghah

Department of Medical Laboratory Science, Delta State University

Email: arthuresa2006@gmail.com
P. M. B. 05, Ozoro-Kwale Road, Ozoro, Delta State

H. Umar

Operational Research Centre in Healthcare, Near East University

Email: arthuresa2006@gmail.com
Near East Boulevard, 99138, Nicosia

J. O. Owheruo

Faculty of Science, Department of Food Science and Technology, Delta State University of Science and Technology

Email: arthuresa2006@gmail.com
Department of Food Science and Technology, Delta State University of Science and Technology P. M. B. 05, Ozoro-Kwale Road, Ozoro, Delta State

P. O. Akpoghelie

Faculty of Science, Department of Food Science and Technology, Delta State University of Science and Technology

Email: arthuresa2006@gmail.com
P. O. Akpoghelie is affiliated with the Faculty of Science, Department of Food Science and Technology, Delta State University of Science and Technology. P. M. B. 05, Ozoro-Kwale Road, Ozoro, Delta State

D. S. Ahmed

Department of Chemical Industries, Institute of Technology-Baghdad, Middle Technical University

Email: arthuresa2006@gmail.com
Department of Chemical Industries, Institute of Technology-Baghdad, Middle Technical University 10074, Baghdad

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Copyright (c) 2025 Isoje E.F., Okoro I.O., Ali B.M., Edo G.I., Yousif E., Okpoghono J., Okoro E.O., Okom S.U., Essaghah A.E., Umar H., Owheruo J.O., Akpoghelie P.O., Ahmed D.S.

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