Clinical heterogeneity of progressive supranuclear palsy


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Progressive supranuclear palsy (PSP) is a sporadic neurodegenerative disease characterized by oculomotor disorders, early onset of postural instability and cognitive dysfunction. Classic form of the disease (Richardson’s syndrome) develops only in 24% of all cases, while other phenotypes are registered in most patients. Clinical manifestations of the various types the PSP, as well as their similarities and differences with other nosological forms of extrapyramidal disorders are described in the current review. New diagnostic criteria of PSP developed by the International Society for the Parkinson's Disease and Movement Disorders in 2017 are discussed. Two clinical cases of PSP in patients of Yakhut ethnic origin are presented: in the first case there was classical variant of the disease (Richardson’s syndrome), and in the second case – a PSP-parkinsonism variant.

作者简介

Alexey Tappakhov

M.K. Ammosov North-Eastern Federal University

编辑信件的主要联系方式.
Email: govorovatatyana@mail.ru
俄罗斯联邦, Yakutsk

Tatiana Popova

M.K. Ammosov North-Eastern Federal University

Email: govorovatatyana@mail.ru
ORCID iD: 0000-0003-1062-1540

D. Sci. (Med.), Deputy director for science

俄罗斯联邦, Yakutsk

Tatiana Govorova

M.K. Ammosov North-Eastern Federal University

Email: govorovatatyana@mail.ru
ORCID iD: 0000-0003-0610-3660

postgraduate student, Department of neurology and psychiatry, Head, Laboratory of neuropsychophysiological research, Medical Institute

俄罗斯联邦, Yakutsk

Alyona Petrova

Republican Hospital No. 2 — The center of the Emergency Medical Care

Email: govorovatatyana@mail.ru

neurologist, Department of neurology

俄罗斯联邦, Yakutsk

参考

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