Отправить статью по E-mail Analysis of NAD and NAD-Dependent Protein Deacetylation in Mouse Tissues
- Авторы: Solovjeva L.V.1, Panchenko A.V.2, Shabalin K.A.3, Nerinovski K.B.4, Yakimov A.P.3, Gubareva E.A.2, Svetlova M.P.1, Mudrak O.S.1, Khodorkovskiy M.A.5, Nikiforov A.A.1,5, Kulikova V.A.1,5
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Учреждения:
- Institute of Cytology, Russian Academy of Sciences
- Petrov National Medical Research Center of Oncology, Ministry of Health of the Russian Federation
- Konstantinov Petersburg Nuclear Physics Institute of the National Research Center Kurchatov Institute
- St. Petersburg State University
- Peter the Great St. Petersburg Polytechnic University
- Выпуск: Том 12, № 6 (2018)
- Страницы: 491-495
- Раздел: Article
- URL: https://ogarev-online.ru/1990-519X/article/view/212808
- DOI: https://doi.org/10.1134/S1990519X18060123
- ID: 212808
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Аннотация
Nicotinamide adenine dinucleotide (NAD) plays a key role in the vital metabolic and regulatory processes in mammals. Disturbance of the NAD level regulation is associated with the development of such serious diseases as pellagra, neurodegenerative and cardiovascular disorders, diabetes, cancer and others. This paper presents an experimental approach that allows to determine the amount of NAD+ in mouse tissues using NMR spectroscopy, as well as the level of NAD+-dependent deacetylation of proteins in the cytosol and mitochondria.
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Об авторах
L. Solovjeva
Institute of Cytology, Russian Academy of Sciences
Email: veronika.a.kulikova@gmail.com
Россия, St. Petersburg, 194064
A. Panchenko
Petrov National Medical Research Center of Oncology, Ministry of Healthof the Russian Federation
Email: veronika.a.kulikova@gmail.com
Россия, St. Petersburg, 197758
K. Shabalin
Konstantinov Petersburg Nuclear Physics Institute of the National Research CenterKurchatov Institute
Email: veronika.a.kulikova@gmail.com
Россия, Gatchina, 188300
K. Nerinovski
St. Petersburg State University
Email: veronika.a.kulikova@gmail.com
Россия, St. Petersburg, 199034
A. Yakimov
Konstantinov Petersburg Nuclear Physics Institute of the National Research CenterKurchatov Institute
Email: veronika.a.kulikova@gmail.com
Россия, Gatchina, 188300
E. Gubareva
Petrov National Medical Research Center of Oncology, Ministry of Healthof the Russian Federation
Email: veronika.a.kulikova@gmail.com
Россия, St. Petersburg, 197758
M. Svetlova
Institute of Cytology, Russian Academy of Sciences
Email: veronika.a.kulikova@gmail.com
Россия, St. Petersburg, 194064
O. Mudrak
Institute of Cytology, Russian Academy of Sciences
Email: veronika.a.kulikova@gmail.com
Россия, St. Petersburg, 194064
M. Khodorkovskiy
Peter the Great St. Petersburg Polytechnic University
Email: veronika.a.kulikova@gmail.com
Россия, St. Petersburg, 195251
A. Nikiforov
Institute of Cytology, Russian Academy of Sciences; Peter the Great St. Petersburg Polytechnic University
Автор, ответственный за переписку.
Email: andrey.nikiforov@gmail.com
Россия, St. Petersburg, 194064; St. Petersburg, 195251
V. Kulikova
Institute of Cytology, Russian Academy of Sciences; Peter the Great St. Petersburg Polytechnic University
Автор, ответственный за переписку.
Email: veronika.a.kulikova@gmail.com
Россия, St. Petersburg, 194064; St. Petersburg, 195251
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