Email this article Phosphocreatine immobilization of the surface of silica and magnetite nanoparticles for targeted drug delivery
- Authors: Korolev D.V.1,2, Evreinova N.V.1,3, Zakharova E.V.4, Gareev K.G.4, Naumysheva E.B.1,5, Postnov D.V.5, Postnov V.N.1,5, Galagudza M.M.1,2
-
Affiliations:
- Almazov National Medical Research Centre
- First Pavlov State Medical University of St. Petersburg
- St. Petersburg State Technological Institute (Technical University)
- St. Petersburg Electrotechnical University “LETI”
- St. Petersburg State University
- Issue: Vol 68, No 5 (2019)
- Pages: 1096-1101
- Section: Full Article
- URL: https://ogarev-online.ru/1066-5285/article/view/243386
- DOI: https://doi.org/10.1007/s11172-019-2525-0
- ID: 243386
Cite item
Open Access
Access granted
Subscription Access
Abstract
A method is proposed for immobilization of anti-ischemic drug phosphocreatine on the surface of aminated silica and magnetite nanoparticles of similar size and shape. The synthesis of spacer and the coordination-ionic drug immobilization technique are described. Magnetite nanoparticles demonstrated much more efficient chemisorption of phosphocreatine than silica nanoparticles. The method was recommended for practical application.
About the authors
D. V. Korolev
Almazov National Medical Research Centre; First Pavlov State Medical University of St. Petersburg
Author for correspondence.
Email: Korolev_DV@almazovcentre.ru
Russian Federation, 2 ul. Akkuratova, St. Petersburg, 197341; 6—8 ul. L’va Tolstogo, St. Petersburg, 197022
N. V. Evreinova
Almazov National Medical Research Centre; St. Petersburg State Technological Institute (Technical University)
Email: Korolev_DV@almazovcentre.ru
Russian Federation, 2 ul. Akkuratova, St. Petersburg, 197341; 26 Moskovsky prosp., St. Petersburg, 190013
E. V. Zakharova
St. Petersburg Electrotechnical University “LETI”
Email: Korolev_DV@almazovcentre.ru
Russian Federation, 5 ul. Prof. Popova, St. Petersburg, 197376
K. G. Gareev
St. Petersburg Electrotechnical University “LETI”
Email: Korolev_DV@almazovcentre.ru
Russian Federation, 5 ul. Prof. Popova, St. Petersburg, 197376
E. B. Naumysheva
Almazov National Medical Research Centre; St. Petersburg State University
Email: Korolev_DV@almazovcentre.ru
Russian Federation, 2 ul. Akkuratova, St. Petersburg, 197341; 7/9 Universitetskaya nab., St. Petersburg, 199034
D. V. Postnov
St. Petersburg State University
Email: Korolev_DV@almazovcentre.ru
Russian Federation, 7/9 Universitetskaya nab., St. Petersburg, 199034
V. N. Postnov
Almazov National Medical Research Centre; St. Petersburg State University
Email: Korolev_DV@almazovcentre.ru
Russian Federation, 2 ul. Akkuratova, St. Petersburg, 197341; 7/9 Universitetskaya nab., St. Petersburg, 199034
M. M. Galagudza
Almazov National Medical Research Centre; First Pavlov State Medical University of St. Petersburg
Email: Korolev_DV@almazovcentre.ru
Russian Federation, 2 ul. Akkuratova, St. Petersburg, 197341; 6—8 ul. L’va Tolstogo, St. Petersburg, 197022
Supplementary files
