Enviar artigo por via de e-mail Phosphocreatine immobilization of the surface of silica and magnetite nanoparticles for targeted drug delivery
- Autores: Korolev D.V.1,2, Evreinova N.V.1,3, Zakharova E.V.4, Gareev K.G.4, Naumysheva E.B.1,5, Postnov D.V.5, Postnov V.N.1,5, Galagudza M.M.1,2
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Afiliações:
- Almazov National Medical Research Centre
- First Pavlov State Medical University of St. Petersburg
- St. Petersburg State Technological Institute (Technical University)
- St. Petersburg Electrotechnical University “LETI”
- St. Petersburg State University
- Edição: Volume 68, Nº 5 (2019)
- Páginas: 1096-1101
- Seção: Full Article
- URL: https://ogarev-online.ru/1066-5285/article/view/243386
- DOI: https://doi.org/10.1007/s11172-019-2525-0
- ID: 243386
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Resumo
A method is proposed for immobilization of anti-ischemic drug phosphocreatine on the surface of aminated silica and magnetite nanoparticles of similar size and shape. The synthesis of spacer and the coordination-ionic drug immobilization technique are described. Magnetite nanoparticles demonstrated much more efficient chemisorption of phosphocreatine than silica nanoparticles. The method was recommended for practical application.
Sobre autores
D. Korolev
Almazov National Medical Research Centre; First Pavlov State Medical University of St. Petersburg
Autor responsável pela correspondência
Email: Korolev_DV@almazovcentre.ru
Rússia, 2 ul. Akkuratova, St. Petersburg, 197341; 6—8 ul. L’va Tolstogo, St. Petersburg, 197022
N. Evreinova
Almazov National Medical Research Centre; St. Petersburg State Technological Institute (Technical University)
Email: Korolev_DV@almazovcentre.ru
Rússia, 2 ul. Akkuratova, St. Petersburg, 197341; 26 Moskovsky prosp., St. Petersburg, 190013
E. Zakharova
St. Petersburg Electrotechnical University “LETI”
Email: Korolev_DV@almazovcentre.ru
Rússia, 5 ul. Prof. Popova, St. Petersburg, 197376
K. Gareev
St. Petersburg Electrotechnical University “LETI”
Email: Korolev_DV@almazovcentre.ru
Rússia, 5 ul. Prof. Popova, St. Petersburg, 197376
E. Naumysheva
Almazov National Medical Research Centre; St. Petersburg State University
Email: Korolev_DV@almazovcentre.ru
Rússia, 2 ul. Akkuratova, St. Petersburg, 197341; 7/9 Universitetskaya nab., St. Petersburg, 199034
D. Postnov
St. Petersburg State University
Email: Korolev_DV@almazovcentre.ru
Rússia, 7/9 Universitetskaya nab., St. Petersburg, 199034
V. Postnov
Almazov National Medical Research Centre; St. Petersburg State University
Email: Korolev_DV@almazovcentre.ru
Rússia, 2 ul. Akkuratova, St. Petersburg, 197341; 7/9 Universitetskaya nab., St. Petersburg, 199034
M. Galagudza
Almazov National Medical Research Centre; First Pavlov State Medical University of St. Petersburg
Email: Korolev_DV@almazovcentre.ru
Rússia, 2 ul. Akkuratova, St. Petersburg, 197341; 6—8 ul. L’va Tolstogo, St. Petersburg, 197022
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