Отправить статью по E-mail Antiarrhythmic Activity of the Flavonoid Fraction of Plantago Major L. Extract
- Авторы: Khushmatov S.S.1, Makhmudov R.R.1
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Учреждения:
- A. S. Sadykov Institute of Bioorganic Chemistry, Academy of Sciences of the Republic of Uzbekistan
- Выпуск: Том 52, № 12 (2019)
- Страницы: 992-995
- Раздел: Article
- URL: https://ogarev-online.ru/0091-150X/article/view/245572
- DOI: https://doi.org/10.1007/s11094-019-01939-8
- ID: 245572
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Аннотация
Antiarrhythmic activity of the flavonoid fraction of Plantago major L. extract (0.05 mg/mL) was studied. The studied fractions were found to lower the frequency of rat cardiac papillary muscle contractions with aconitine-induced (1 μM) arrythmia in vitro. An analysis of literature and experimental data suggested that the antiarrhythmic effects of the studied flavonoid fractions may have been related to functional modulation of Na+- and Ca2+-channels in cardiomyocytes.
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Sh. Khushmatov
A. S. Sadykov Institute of Bioorganic Chemistry, Academy of Sciences of the Republic of Uzbekistan
Автор, ответственный за переписку.
Email: Khushmatov_Sh.S@bk.ru
Узбекистан, 83 M. Ulugbek St., Tashkent, 100125
R. Makhmudov
A. S. Sadykov Institute of Bioorganic Chemistry, Academy of Sciences of the Republic of Uzbekistan
Email: Khushmatov_Sh.S@bk.ru
Узбекистан, 83 M. Ulugbek St., Tashkent, 100125
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