Email this article Antiarrhythmic Activity of the Flavonoid Fraction of Plantago Major L. Extract
- Authors: Khushmatov S.S.1, Makhmudov R.R.1
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Affiliations:
- A. S. Sadykov Institute of Bioorganic Chemistry, Academy of Sciences of the Republic of Uzbekistan
- Issue: Vol 52, No 12 (2019)
- Pages: 992-995
- Section: Article
- URL: https://ogarev-online.ru/0091-150X/article/view/245572
- DOI: https://doi.org/10.1007/s11094-019-01939-8
- ID: 245572
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Abstract
Antiarrhythmic activity of the flavonoid fraction of Plantago major L. extract (0.05 mg/mL) was studied. The studied fractions were found to lower the frequency of rat cardiac papillary muscle contractions with aconitine-induced (1 μM) arrythmia in vitro. An analysis of literature and experimental data suggested that the antiarrhythmic effects of the studied flavonoid fractions may have been related to functional modulation of Na+- and Ca2+-channels in cardiomyocytes.
About the authors
Sh. S. Khushmatov
A. S. Sadykov Institute of Bioorganic Chemistry, Academy of Sciences of the Republic of Uzbekistan
Author for correspondence.
Email: Khushmatov_Sh.S@bk.ru
Uzbekistan, 83 M. Ulugbek St., Tashkent, 100125
R. R. Makhmudov
A. S. Sadykov Institute of Bioorganic Chemistry, Academy of Sciences of the Republic of Uzbekistan
Email: Khushmatov_Sh.S@bk.ru
Uzbekistan, 83 M. Ulugbek St., Tashkent, 100125
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