Enviar artigo por via de e-mail Antiarrhythmic Activity of the Flavonoid Fraction of Plantago Major L. Extract
- Autores: Khushmatov S.S.1, Makhmudov R.R.1
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Afiliações:
- A. S. Sadykov Institute of Bioorganic Chemistry, Academy of Sciences of the Republic of Uzbekistan
- Edição: Volume 52, Nº 12 (2019)
- Páginas: 992-995
- Seção: Article
- URL: https://ogarev-online.ru/0091-150X/article/view/245572
- DOI: https://doi.org/10.1007/s11094-019-01939-8
- ID: 245572
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Resumo
Antiarrhythmic activity of the flavonoid fraction of Plantago major L. extract (0.05 mg/mL) was studied. The studied fractions were found to lower the frequency of rat cardiac papillary muscle contractions with aconitine-induced (1 μM) arrythmia in vitro. An analysis of literature and experimental data suggested that the antiarrhythmic effects of the studied flavonoid fractions may have been related to functional modulation of Na+- and Ca2+-channels in cardiomyocytes.
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Sh. Khushmatov
A. S. Sadykov Institute of Bioorganic Chemistry, Academy of Sciences of the Republic of Uzbekistan
Autor responsável pela correspondência
Email: Khushmatov_Sh.S@bk.ru
Uzbequistão, 83 M. Ulugbek St., Tashkent, 100125
R. Makhmudov
A. S. Sadykov Institute of Bioorganic Chemistry, Academy of Sciences of the Republic of Uzbekistan
Email: Khushmatov_Sh.S@bk.ru
Uzbequistão, 83 M. Ulugbek St., Tashkent, 100125
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