Local Anesthetic Activity of a Promising Piperidine Derivative (LAS-54) in Combination with Epinephrine

G. M. Pichkhadze; G. S. Smagulova; D. M. Kadyrova; K. D. Praliev; V. K. Yu

doi:10.1007/s11094-016-1498-7

Local Anesthetic Activity of a Promising Piperidine Derivative (LAS-54) in Combination with Epinephrine

Авторы: Pichkhadze G.M.¹, Smagulova G.S.¹, Kadyrova D.M.¹, Praliev K.D.², Yu V.K.²
Учреждения:
1. S. D. Asfendiyarov Kazakh National Medical University
2. A. B. Bekturov Institute of Chemical Sciences, Ministry of Education and Science of the Republic of Kazakhstan
Выпуск: Том 50, № 9 (2016)
Страницы: 600-602
Раздел: Article
URL: https://ogarev-online.ru/0091-150X/article/view/244445
DOI: https://doi.org/10.1007/s11094-016-1498-7
ID: 244445

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Аннотация

Results from studies of the local anesthetic activity of LAS-54 [4-(benzoyloxy)-3-butoxypiperidinium chloride] (synthesized at the Laboratory of the Chemistry of Synthetic and Natural Drugs, Bekturov Institute of Chemical Sciences) in combination with epinephrine are presented. It was found that joint application of the vasoconstrictor with LAS-54, especially at low concentrations, prolonged infiltration, conduction, and spinal anesthesia.

Ключевые слова

conduction, infiltration, and spinal anesthesia, piperidine, vasoconstrictor, epinephrine