Local Anesthetic Activity of a Promising Piperidine Derivative (LAS-54) in Combination with Epinephrine


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Results from studies of the local anesthetic activity of LAS-54 [4-(benzoyloxy)-3-butoxypiperidinium chloride] (synthesized at the Laboratory of the Chemistry of Synthetic and Natural Drugs, Bekturov Institute of Chemical Sciences) in combination with epinephrine are presented. It was found that joint application of the vasoconstrictor with LAS-54, especially at low concentrations, prolonged infiltration, conduction, and spinal anesthesia.

作者简介

G. Pichkhadze

S. D. Asfendiyarov Kazakh National Medical University

Email: chem@folium.ru
哈萨克斯坦, Almaty

G. Smagulova

S. D. Asfendiyarov Kazakh National Medical University

Email: chem@folium.ru
哈萨克斯坦, Almaty

D. Kadyrova

S. D. Asfendiyarov Kazakh National Medical University

Email: chem@folium.ru
哈萨克斯坦, Almaty

K. Praliev

A. B. Bekturov Institute of Chemical Sciences, Ministry of Education and Science of the Republic of Kazakhstan

Email: chem@folium.ru
哈萨克斯坦, Almaty

V. Yu

A. B. Bekturov Institute of Chemical Sciences, Ministry of Education and Science of the Republic of Kazakhstan

Email: chem@folium.ru
哈萨克斯坦, Almaty

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