Pulsed Dendritic Cells for the Therapy of Experimental Glioma


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We obtained the morphologically, cytofluorometrically, and functionally mature dendritic cells from rats that were pulsed with antigens of the C6 glioma tissue extract. The concentrations of angiogenesis antigens (VEGF, VEGFR-1, and VEGFR-2) and periglioma zone proteins (GFAP, connexin 43, and BSAT1) in the pulsing extract were measured by ELISA. Our results drove us to a conclusion that despite mature phenotype of pulsed dendritic cell, the antigenic composition of glioma tissue extracts should be modified.

作者简介

I. Chekhonin

V. P. Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russian Federation

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Email: ivan-chekhonin@yandex.ru
俄罗斯联邦, Moscow

O. Gurina

V. P. Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russian Federation

Email: ivan-chekhonin@yandex.ru
俄罗斯联邦, Moscow

S. Cherepanov

Department of Medical Nanobiotechnologies, Medical Biological Faculty, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation

Email: ivan-chekhonin@yandex.ru
俄罗斯联邦, Moscow

M. Abakumov

Department of Medical Nanobiotechnologies, Medical Biological Faculty, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation

Email: ivan-chekhonin@yandex.ru
俄罗斯联邦, Moscow

K. Ionova

V. P. Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russian Federation

Email: ivan-chekhonin@yandex.ru
俄罗斯联邦, Moscow

D. Zhigarev

V. P. Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russian Federation

Email: ivan-chekhonin@yandex.ru
俄罗斯联邦, Moscow

A. Makarov

V. P. Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russian Federation

Email: ivan-chekhonin@yandex.ru
俄罗斯联邦, Moscow

V. Chekhonin

V. P. Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russian Federation; Department of Medical Nanobiotechnologies, Medical Biological Faculty, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation

Email: ivan-chekhonin@yandex.ru
俄罗斯联邦, Moscow; Moscow

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