Pulsed Dendritic Cells for the Therapy of Experimental Glioma


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Толық мәтін

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Рұқсат жабық Тек жазылушылар үшін

Аннотация

We obtained the morphologically, cytofluorometrically, and functionally mature dendritic cells from rats that were pulsed with antigens of the C6 glioma tissue extract. The concentrations of angiogenesis antigens (VEGF, VEGFR-1, and VEGFR-2) and periglioma zone proteins (GFAP, connexin 43, and BSAT1) in the pulsing extract were measured by ELISA. Our results drove us to a conclusion that despite mature phenotype of pulsed dendritic cell, the antigenic composition of glioma tissue extracts should be modified.

Авторлар туралы

I. Chekhonin

V. P. Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russian Federation

Хат алмасуға жауапты Автор.
Email: ivan-chekhonin@yandex.ru
Ресей, Moscow

O. Gurina

V. P. Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russian Federation

Email: ivan-chekhonin@yandex.ru
Ресей, Moscow

S. Cherepanov

Department of Medical Nanobiotechnologies, Medical Biological Faculty, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation

Email: ivan-chekhonin@yandex.ru
Ресей, Moscow

M. Abakumov

Department of Medical Nanobiotechnologies, Medical Biological Faculty, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation

Email: ivan-chekhonin@yandex.ru
Ресей, Moscow

K. Ionova

V. P. Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russian Federation

Email: ivan-chekhonin@yandex.ru
Ресей, Moscow

D. Zhigarev

V. P. Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russian Federation

Email: ivan-chekhonin@yandex.ru
Ресей, Moscow

A. Makarov

V. P. Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russian Federation

Email: ivan-chekhonin@yandex.ru
Ресей, Moscow

V. Chekhonin

V. P. Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russian Federation; Department of Medical Nanobiotechnologies, Medical Biological Faculty, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation

Email: ivan-chekhonin@yandex.ru
Ресей, Moscow; Moscow

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