Characterization of an Acellular Dermal Matrix Obtained by Different Detergent-Enzymatic Methods

N. N. Sarbaeva; M. N. Milyakova; V. V. Rossinskaya; O. V. Gribkova; D. A. Dolgushkin

doi:10.1007/s10527-017-9707-6

Characterization of an Acellular Dermal Matrix Obtained by Different Detergent-Enzymatic Methods

Авторлар: Sarbaeva N.N.¹, Milyakova M.N.¹, Rossinskaya V.V.¹, Gribkova O.V.¹, Dolgushkin D.A.¹
Мекемелер:
1. Samara State Medical University, Ministry of Health of the Russian Federation
Шығарылым: Том 51, № 3 (2017)
Беттер: 166-169
Бөлім: Article
URL: https://ogarev-online.ru/0006-3398/article/view/235030
DOI: https://doi.org/10.1007/s10527-017-9707-6
ID: 235030

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Аннотация

Acellular dermal matrixes (ADM) for reconstructive surgery were made by treating skin samples from rats and humans with sodium dodecylsulfate (SDS), sodium deoxycholate (DOC), saponin, and DNase. A mixture of SDS and DOC removed cell residues effectively, though the ADM had cytotoxic properties. After treatment with 2% DOC, there was no cytotoxic effect and the resulting material contained 27-202 ng/mg dry weight DNA and from 0.07 to 2.6% fat, depending on the source of the samples.