Gender peculiarities of critical lower limb ischemia

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BACKGROUND: Development of critical ischemia of lower limbs in patients with atherosclerosis causes negative consequences due to the high probability of detecting multilevel changes, as well as identifying coronary and carotid pools.

АIM: The aim of the study was to investigate gender differences in critical lower limb ischemia of atherosclerotic genesis following reconstructive interventions.

MATERIALS AND METHODS: Arterial reconstructions have been performed in 261 patients with peripheral atherosclerosis (95 women and 166 men). The specific features of reconstructive interventions have been taken into account; complications and the number of amputations have been analyzed in the early period.

RESULTS: Higher pulse pressure has been registered in the female group; tibial arteries have been affected significantly more frequently (p < 0,05). Thrombosis of the operated segment has been observed more frequently in the male patients at the stage of critical ischemia; in the case of claudication the complications were sporadic.

CONCLUSIONS: The best results of reconstructive care in men and women with peripheral atherosclerosis at the claudication stage determine the vector of active tactics in the absence of conservative treatment results.

作者简介

Nikolay I. Glushkov

North-Western State Medical University named after I.I. Mechnikov

Email: nikolay.glushkov@szgmu.ru
ORCID iD: 0000-0001-8146-4728

MD, Dr. Sci. (Med.), Professor

俄罗斯联邦, 47 Piskarevsky Ave., Saint Petersburg, 195067

Petr D. Puzdriak

North-Western State Medical University named after I.I. Mechnikov

Email: hirurg495@yandex.ru
ORCID iD: 0000-0003-2631-3622
Scopus 作者 ID: 57194489779
Researcher ID: K-9787-2016

MD

俄罗斯联邦, 47 Piskarevsky Ave., Saint Petersburg, 195067

Anastasia N. Agurbash

North-Western State Medical University named after I.I. Mechnikov

Email: nastaagurbash@mail.ru
ORCID iD: 0000-0003-1247-3481
俄罗斯联邦, 47 Piskarevsky Ave., Saint Petersburg, 195067

Anatoly V. Razepin

North-Western State Medical University named after I.I. Mechnikov

Email: razepint@rambler.ru
ORCID iD: 0000-0003-0470-4681
俄罗斯联邦, 47 Piskarevsky Ave., Saint Petersburg, 195067

Mikhail A. Ivanov

North-Western State Medical University named after I.I. Mechnikov

编辑信件的主要联系方式.
Email: iv30407302007@yandex.ru
ORCID iD: 0000-0002-4756-6488

MD, Dr. Sci. (Med.), Professor

俄罗斯联邦, 47 Piskarevsky Ave., Saint Petersburg, 195067

参考

  1. Krishna SM, Moxon JV, Golledge J. A Review of the pathophysiology and potential biomarkers for peripheral artery disease. Int J Mol Sci. 2015;16(5):11294–11322. doi: 10.3390/ijms160511294
  2. Matsushita K, Kwak L, Yang C, et al. High-sensitivity cardiac troponin and natriuretic peptide with risk of lower-extremity peripheral artery disease: the Atherosclerosis Risk in Communities (ARIC) Study. Eur Heart J. 2018;39(25):2412–2419. doi: 10.1093/eurheartj/ehy106
  3. Puzdriak PD, Shlomin VV, Bondarenko PB, et al. Comparison of the results of hybrid and open surgical treatment of multilevel arterial disease of lower extremities (in Russian only). Russian Journal of Cardiology and Cardiovascular Surgery. 2019;12(3):227–234. (In Russ.). doi: 10.17116/kardio201912031227
  4. Glushkov NI, Potashov TA, Ivanov MA, et al. Optimal terms of revascularization in patients with peripheral atherosclerosis Preventive and Clinical Medicine. 2020;3(76):70–76. (In Russ.)
  5. Man JJ, Beckman JA, Jaffe IZ. Sex as a biological variable in atherosclerosis. Circ Res. 2020;126(9):1297–1319. doi: 10.1161/CIRCRESAHA.120.315930
  6. Jelani Q, Mena-Hurtado C, Burg M, et al. Relationship between depressive symptoms and health status in peripheral artery disease: role of sex differences. J Am Heart Assoc. 2020;9(16):e014583. doi: 10.1161/JAHA.119.014583
  7. Pérez-López FR, Larrad-Mur L, Kallen A, et al. Differences in cardiovascular disease: hormonal and biochemical influences. Reprod Sci. 2010;17(6):511–531. doi: 10.1177/1933719110367829
  8. Fanlo-Maresma M, Candás-Estébanez B, Esteve-Luque V, et al. Asymptomatic carotid atherosclerosis cardiovascular risk factors and common hypertriglyceridemia genetic variants in patients with systemic erythematosus lupus. J Clin Med. 2021;10(10):2218. doi: 10.3390/jcm10102218
  9. Giannopoulos S, Shammas NW, Cawich I, et al. Sex-Related Differences in the Outcomes of endovascular interventions for chronic limb-threatening ischemia: results from the liberty 360 study. Vasc Health Risk Manag. 2020;16:271–284. doi: 10.2147/VHRM.S246528
  10. Altreuther M, Mattsson E. Long-term results after femoral thrombendarterectomy combined with simultaneous endovascular intervention in intermittent claudication and critical ischemia. SAGE Open Med. 2020;8:2050312119900860. doi: 10.1177/2050312119900860
  11. Muluk SC, Muluk VS, Kelley ME, et al. Outcome events in patients with claudication: a 15-year study in 2777 patients. J Vasc Surg. 2001;33(2):251–257. doi: 10.1067/mva.2001.112210

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2. 图1 研究组胫骨节段病变频率和血管内治疗需求的差异 Fig. 1. Differences in the incidence of tibial segment involvement and needs for endovascular care in the study groups

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3. 图2 分析组围手术期失血量的价值 Fig. 2. The value of perioperative blood loss in the analysis groups

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4. 图3 在下肢严重缺血和跛行的背景下，分析组中手术节段血栓形成的频率。CLI-严重的下肢缺血 Fig. 3. The frequency of thrombosis of the operated segment in the analyzed groups against the background of critical ischemia of the lower extremities and claudication. CLI — critical lower limb ischemia

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版权所有 © Glushkov N., Puzdriak P., Agurbash A., Razepin A., Ivanov M., 2021

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