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发表评论 Predictors of the development of cardiac arrhythmias in women after induction of superovulation in vitro fertilization
- 作者: Vakareva V.V.1, Avdeeva M.V.1, Scheglova L.V.1, Bondarev S.A.1, Voronkov P.B.1
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隶属关系:
- St. Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
- 期: 卷 10, 编号 5 (2019)
- 页面: 57-65
- 栏目: Original studies
- URL: https://ogarev-online.ru/pediatr/article/view/19157
- DOI: https://doi.org/10.17816/PED10557-65
- ID: 19157
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详细
The article presents the results of a clinical and instrumental examination of 80 healthy women (average age 32,31 ± 3,57 years) in order to assess the heart rhythm disturbances after induction of superovulation during in vitro fertilization. All women were examined twice – before and after induction of superovulation during extracorporeal fertilization. Clinical and instrumental examination included: electrocardiography at rest; echocardiography; 24-hour ECG monitoring with heart rate variability analysis; 24-hour blood pressure monitoring. Induction of superovulation is associated with a significant increase in mean daily HR max (р < 0,01), and consequently with an increase in myocardial oxygen demand. It has been established that induction of superovulation contributes to the development of supraventricular arrhythmias (р < 0,01) and an increase in episodes of apnea/hypnea (р < 0,01). Regression analysis revealed predictors of supraventricular arrhythmias after induction of superovulation, including adverse circadian heart rate profile, adverse circadian blood pressure profile, impaired autonomic regulation of heart activity (р < 0,01). It was shown that the appearance of rhythm disturbances is associated with both the initial functional state of the cardiovascular system and its response to the induction of superovulation. It was established a correlation between the estradiol concentration and the increase of daily average heart rate after induction of superovulation (r = 0,30, р < 0,05), apnea/hypnea index after induction of superovulation (r = 0,34, р < 0,05). Conclusion. Superovulation induction may exacerbate existing chronic cardiovascular diseases. Due to the adverse effect of superovulation induction on the daily heart rate profile, women need to evaluate the functional state of the cardiovascular system during in vitro fertilization planning. This will prepare the woman for the upcoming procedure and avoid adverse reactions from the cardiovascular system in response to stimulation of superovulation in vitro fertilization.
作者简介
Victoria Vakareva
St. Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
编辑信件的主要联系方式.
Email: barbora83@mail.ru
Postgraduate Student, Department of Family Medicine AF and DPO
俄罗斯联邦, Saint PetersburgMarina Avdeeva
St. Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Email: Lensk69@mail.ru
MD, PhD, Dr Med Sci, Professor, Department of Family Medicine AF and DPO
俄罗斯联邦, Saint PetersburgLarisa Scheglova
St. Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Email: shcheglovalar@mail.ru
MD, PhD, Dr Med Sci, Professor, Head, Department of Family Medicine AF and DPO
俄罗斯联邦, Saint PetersburgSergey Bondarev
St. Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Email: sabondarev@yandex.com
MD, PhD, Dr Med Sci, Associate Professor, Department of Hospital Therapy with Military Therapy and Occupational Medicine Courses
俄罗斯联邦, Saint PetersburgPavel Voronkov
St. Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Email: pbvoronkov@yandex.ru
MD, PhD, Associate Professor, Department of Family Medicine AF and DPO
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