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Post a Comment Features of severe forms of new coronavirus infection (COVID-19) in children
- Authors: Bannova S.L1, Ivanov D.O.1, Alexandrovich Y.S.1, Timchenko V.N.1, Kaplina T.A.1, Kondratiev G.V.1, Felker E.Y.1, Ibragimov R.N.1, Razgon M.V.1, Revnova M.O.1, Komissarova M.Y.1, Novikova V.P.1
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Affiliations:
- Saint Petersburg State Pediatric Medical University
- Issue: Vol 14, No 5 (2023)
- Pages: 5-13
- Section: Editorial
- URL: https://ogarev-online.ru/pediatr/article/view/252873
- DOI: https://doi.org/10.17816/PED625937
- ID: 252873
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Abstract
BACKGROUND: The problem of the complicated course of COVID-19 and deaths in children with severe comorbid pathology is relevant. Severe forms of the disease are often the cause of critical conditions and deaths, including decompensated respiratory failure, acute respiratory distress syndrome, septic shock, cardiac, hepatic, renal insufficiency, coagulation disorders, damage to the central nervous system.
AIM: The aim is to analyze the features of the course of COVID-19 in children who require mandatory hospitalization in specialized hospitals for background pathology, to identify predictors of the development of severe forms of COVID-19 in order to choose the optimal ways of treating this pathology.
MATERIALS AND METHODS: Under the supervision of the St. Petersburg State Pediatric Medical University in the department for children with new coronavirus infection COVID-19 with intensive care and intensive care wards in the period 2020–2022 with a confirmed diagnosis of “new coronavirus infection” there were 791 patients aged 0 to 17 years. The diagnosis was made on the basis of clinical and epidemiological data, the results of a comprehensive laboratory and instrumental study. The severity of the disease was determined in accordance with the methodological recommendations of the Ministry of Health of the Russian Federation.
RESULTS: The severe form of COVID-19 was diagnosed in 34 patients out of 791 (4.3%). Adverse outcomes were 1.4%. In 27 out of 34 children (79.4%), new coronavirus infection occurred against the background of severe comorbid pathology. Pneumonia was diagnosed in 91.2% of cases. 88.2% of patients needed oxygen therapy.
CONCLUSIONS: Severe forms of COVID-19 in children are characterized by high fever with severe intoxication, respiratory tract damage with a significant volume of lung damage (CT-3 and CT-4) with the development of multiple organ failure. Predictors that require mandatory hospitalization in specialized hospitals for background pathology in severe forms of COVID-19 are: primary immunodeficiency conditions, oncohematological pathology with postcytostatic aplasia of hematopoiesis, severe organic lesions of the central nervous system, epilepsy, protein-energy deficiency of 3–4 degrees, bronchopulmonary dysplasia, atypical emolytic uremic syndrome with acute kidney damage. Comprehensive treatment of such patients should be carried out by a multidisciplinary team in a specialized department with extensive diagnostic and therapeutic capabilities.
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##article.viewOnOriginalSite##About the authors
Svetlana L Bannova
Saint Petersburg State Pediatric Medical University
Author for correspondence.
Email: svetlanalb81@mail.ru
ORCID iD: 0000-0003-1351-1910
SPIN-code: 9654-9386
MD, PhD, Assistant Professor, Department of Infectious Diseases in Children named after Professor M.G. Danilevich
Russian Federation, Saint PetersburgDmitry O. Ivanov
Saint Petersburg State Pediatric Medical University
Email: doivanov@yandex.ru
ORCID iD: 0000-0002-0060-4168
SPIN-code: 4437-9626
Rector, Head of the Department of Neonatology with courses of Neurology and Obstetrics and Gynecology
Russian Federation, Saint PetersburgYuriy S. Alexandrovich
Saint Petersburg State Pediatric Medical University
Email: jalex1963@mail.ru
ORCID iD: 0000-0002-2131-4813
SPIN-code: 2225-1630
MD, PhD, Dr. Sci. (Medicine), Professor, Head of the Department of Anesthesiology and Intensive Care and Emergency Pediatrics Postgraduate Education
Russian Federation, Saint PetersburgVladimir N. Timchenko
Saint Petersburg State Pediatric Medical University
Email: timchenko220853@yandex.ru
ORCID iD: 0000-0002-4068-1731
SPIN-code: 8594-0751
MD, PhD, Dr. Sci. (Medicine), Professor, Department of Infectious Diseases in Children named after Professor M.G. Danilevich
Russian Federation, Saint PetersburgTatyana A. Kaplina
Saint Petersburg State Pediatric Medical University
Email: k.kta@yandex.ru
ORCID iD: 0000-0003-1659-2058
SPIN-code: 1381-9580
MD, PhD, Assistant Professor, Department of Infectious Diseases in Children named after Professor M.G. Danilevich
Russian Federation, Saint PetersburgGleb V. Kondratiev
Saint Petersburg State Pediatric Medical University
Email: spbgvk@mail.ru
ORCID iD: 0000-0002-1462-6907
SPIN-code: 9092-3185
MD, PhD, Assistant Professor, Department of Oncology, Pediatric Oncology and Radiation Therapy
Russian Federation, Saint PetersburgEvgeniy Yu. Felker
Saint Petersburg State Pediatric Medical University
Email: felkeru@gmail.com
ORCID iD: 0000-0002-7780-8871
SPIN-code: 9244-0361
MD, PhD, Head of the Department of Anesthesiology-Intensive Care
Russian Federation, Saint PetersburgRustam N. Ibragimov
Saint Petersburg State Pediatric Medical University
Email: rustyibr@gmail.com
ORCID iD: 0000-0002-5009-1938
SPIN-code: 8657-3664
anesthesiologist-resuscitator of the Department of Anesthesiology-Intensive Care
Russian Federation, Saint PetersburgMarina V. Razgon
Saint Petersburg State Pediatric Medical University
Email: mar.krupskaia@gmail.com
ORCID iD: 0009-0006-5157-1374
anesthesiologist-resuscitator of the Department of Anesthesiology-Intensive Care
Russian Federation, Saint PetersburgMaria O. Revnova
Saint Petersburg State Pediatric Medical University
Email: revnoff@mail.ru
ORCID iD: 0000-0002-3537-7372
SPIN-code: 5474-9268
MD, PhD, Dr. Sci. (Medicine), Professor, Head of Outpatient Pediatrics Department named after Academician A.F
Russian Federation, Saint PetersburgMarina Yu. Komissarova
Saint Petersburg State Pediatric Medical University
Email: vtmp@gpma.ru
ORCID iD: 0000-0002-1533-4498
SPIN-code: 1809-1118
MD, PhD, Deputy Chief Physician for Hospitalization, Senior Researcher at the Laboratory of Medical and Social Problems in Pediatrics of SIC
Russian Federation, Saint PetersburgValeria P. Novikova
Saint Petersburg State Pediatric Medical University
Email: novikova-vp@mail.ru
ORCID iD: 0000-0002-0992-1709
SPIN-code: 1875-8137
MD, PhD, Dr. Sci. (Medicine), Professor, Head of the Department of Propaedeutics of Children's Diseases with a Course in General Child Care, Head of the Laboratory of Medical and social problems in pediatrics
Russian Federation, Saint PetersburgReferences
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