Features of obesity treatment in patients with gastroesophageal reflux disease
- Authors: Andreeva EI1
-
Affiliations:
- Stavropol State Medical University
- Issue: Vol 99, No 1 (2018)
- Pages: 78-84
- Section: Reviews
- URL: https://ogarev-online.ru/kazanmedj/article/view/7813
- DOI: https://doi.org/10.17816/KMJ2018-078
- ID: 7813
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Abstract
In the past few decades, the worldwide prevalence of such nosological forms as gastroesophageal reflux disease and obesity has been increasing. The combination of these pathologies is more often observed in patients who have nutrition and lifestyle issues, as well as genetic predisposition to these nosologies. Patients with obesity are noted to have predisposition to diaphragmatic hernias and mechanical damage of gastroesophageal junction, which occurs against the background of increased intragastric pressure and increased pressure gradient between the stomach and esophagus, as well as due to extension of the proximal part of the stomach. One of the basic pathogenetic moments of gastroesophageal reflux disease is spontaneous relaxation of the lower esophageal sphincter. According to recent studies, in obesity the frequency of postprandial spontaneous relaxation of the lower esophageal sphincter increases even in the absence of diaphragmatic hernia, non-erosive gastroesophageal reflux disease and reflux esophagitis. The variety of metabolic disorders observed in these patients requires a comprehensive approach to treatment, aimed both at effective reduction of the acid-peptic factor and at correction of excessive body weight. Both non-pharmacological and pharmacological methods are distinguished among the main treatment directions for both components of this combined pathology. An important role in therapy is given to activities that contribute to the maintenance of healthy lifestyle: smoking cessation, weight loss, dietary nutrition, health-improving physical culture. Among medications for patients with gastroesophageal reflux disease and obesity, which allow achieving an optimal acid-reducing effect, specific attention is assigned to a group of proton pump inhibitors (H+/K+-ATPase inhibitors), which have a lower affinity for hepatic cytochrome P450 enzyme system, do not affect its activity and do not clinically significantly cross-react with other drugs.
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##article.viewOnOriginalSite##About the authors
E I Andreeva
Stavropol State Medical University
Author for correspondence.
Email: eandreeva-doctor@yandex.ru
Stavropol, Russia
References
- Katz P.O., Gerson L.B., Vela M.F. Guidelines for the diagnosis and management of gastroesophageal reflux disease. Am. J. Gastroenterol. 2013; 108: 308–328. doi: 10.1038/ajg.2012.444.
- Krentz A.J. Management of type 2 diabetes in the obese patient current concerns and emerging therapies. Curr. Med. Res. Opin. 2008; 24 (2): 401–417. doi: 10.1185/030079908X219661.
- Kurukulasuriya R., Banerji M.A., Chaiken R., Lebovitz H. Selective decrease in visceral fat is associated with weight loss during metformin treatment in African Americans with type 2 diabetes. Diabetes. 1999; A315.
- Norris S.L., Lee N., Thakurta S., Chan B.K. Exenatide efficacy and safety: a systematic review. Diabet. Med. 2009; 26 (9): 837–846. DOI: j.1464-5491.2009.02790.x.
- Huerta-Iga F., Tamayo-de la Cuesta J., Noble-Lugo A. et al. Consenso mexicano de enfermedad por reflujo gastroesofбgico (Parte I). Rev. Gastroenterol. Mex. 2012; 77: 193–213. doi: 10.1016/j.rgmx.2012.10.002.
- Salis G. Systematic review: Epidemiology of gastroesophageal reflux disease in Latin America. Acta Gastroenterol. Latinoam. 2011; 41: 60–69. PMID: 21539070.
- Sandler B.J., Rumbaut R., Swain C.P. et al. One-year human experience with a novel endoluminal, endoscopic gastric bypass sleeve for morbid obesity. Surg. Endosc. 2015; 29: 3298–3303. doi: 10.1007/s00464-015-4081-5.
- Cange L., Johnsson E., Rydholm H. et al. Baclofen-mediated gastrooesophageal acid reflux control in patients with established reflux disease. Aliment. Pharmacol. Ther. 2002; 16: 869–873. doi: 10.1046/j.1365-2036.2002.01250.x.
- Delavari A., Morado G., Elahi E. et al. Gastroesophageal reflux disease burden in Iran. Arch. Iran Med. 2015; 18: 85–88. PMID: 25644795.
- Goldenberg R., Clement M., Hanna A. et al. Pharmacologic managment of type 2 diabetes: 2016 Interim update. Can. J. Diabetes. 2016; 40 (3): 193–195. doi: 10.1016/j.jcjd.2016.02.006.
- Lazebnik L.B., Zvenigorodskaya L.A. Metabolicheskiy sindrom i organy pishchevareniya. (Metabolic syndrome and digestive organs.) Moscow: Anakharsis. 2009; 345 р. (In Russ.)
- Fuchs K.H., Babic B., Breithaupt W. et al. EAES recommendations for the management of gastroesophageal reflux disease. Surg. Endosc. 2014; 28: 1753–1773. doi: 10.1007/s00464-014-3431-z.
- Tsoukali E., Sifrim D. Investigation of extraesophageal gastroesophageal reflux disease. Ann. Gastroenterol. 2013; 26 (4): 290–295. PMID: 24714277.
- Mocanu M.A., Diculescu M., Dumitrescu M. Gastroesophageal reflux and metabolic syndrome. Rev. Med. Chir. Soc. Med. Nat. Iasi. 2013; 117 (3): 605–609. PMID: 24502023.
- Uspenskiy Yu.P., Balukova E.V., Baryshnikova N.V. Gastroesophageal reflux disease in patients with obesity. Poliklinika. 2015; (1-1): 14–16. (In Russ.)
- El-Serag H.B., Satia J.A., Rabeneck L. Dietary intake and the risk of gastro-oesophageal reflux disease: a cross sectional study in volunteers. Gut. 2005; 54: 11–17. doi: 10.1136/gut.2004.040337.
- Roman S., Pandolfino J.E., Woodland P. et al. Testing for gastroesophageal reflux in the 21st century. Ann. NY Acad. Sci. 2011; 1232: 358–364. doi: 10.1111/j.1749-6632.2011.06066.x.
- Festi D., Scaioli E., Baldi F. et al. Body weight, lifestyle, dietary habits and gastroesophageal reflux disease. World J. Gastroenterol. 2009; 15: 1690–1701. doi: 10.3748/wjg.15.1690.
- Khan A., Ren-Fielding C., Traube M. Potentially reversible pseudoachalasia after laparoscopic adjustable gastric banding. J. Clin. Gastroenterol. 2011; 45: 775–779. doi: 10.1097/MCG.0b013e318226ae14.
- Zvenigorodskaya L.A., Bondarenko E.Yu., Khomeriki S.G. Clinical and morphological features of gastroesophageal reflux disease in patients with abdominal obesity. Consilium Medicum. 2010; 12 (8): 5–9. (In Russ.)
- Kato M., Watabe K., Hamasaki T. et al. Association of low serum adiponectin levels with erosive esophagitis in men: an analysis of 2405 subjects undergoing physical check-ups. J. Gastroenterol. 2011; 46: 1361–1367. doi: 10.1007/s00535-011-0453-3.
- Howard D.D., Caban A.M., Cendan J.C., Ben-David K. Gastroesophageal reflux after sleeve gastrectomy in morbidly obese patients. Surg. Obes. Relat. Dis. 2011; 7: 709–713. doi: 10.1016/j.soard.2011.08.003.
- Aslam M., Slaughter J., Goutte M. et al. Nonlinear relationship between body mass index and esophageal acid exposure in the extraesophageal manifestations of reflux. Clin. Gastroenterol. Hepatol. 2012; 10 (8): 874–878. doi: 10.1016/j.cgh.2011.12.032.
- Roman S., Pandolfino J.E. Environmental — lifestyle related factors. Best Pract. Res. Clin. Gastroenterol. 2010; 24: 847–859. doi: 10.1016/j.bpg.2010.09.010.
- Woodman G., Cywes R., Billy H. et al. Effect of adjustable gastric banding on changes in gastroesophageal reflux disease (GERD) and quality of life. Curr. Med. Res. Opin. 2012; 28: 581–589. doi: 10.1185/03007995.2012.666962.
- Oh J.H. Gastroesophageal reflux disease: recent advances and its association with sleep. Ann. NY Acad. Sci. 2016, 1380: 195–203. doi: 10.1111/nyas.13143.
- Lee W.J., Han M.L., Ser K.H. et al. Laparoscopic Nissen fundoplication with gastric plication as a potential treatment of morbidly obese patients with GERD, first experience and results. Obes. Surg. 2014; 24: 1447–1452. doi: 10.1007/s11695-014-1223-0.
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