电邮这篇文章 Kisspeptin and polycystic ovary syndrome - is there any connection?
- 作者: Yarmolinskaya M.I.1, Ganbarli N.F.1, Tkachenko N.N.1, Nikolaeva V.I.1, Tolibova G.K.1, Tral T.G.1, Rulev V.V.1, Tsypurdeeva A.A.1
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隶属关系:
- Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
- 期: 卷 66, 编号 6 (2017)
- 页面: 73-80
- 栏目: Articles
- URL: https://ogarev-online.ru/jowd/article/view/7686
- DOI: https://doi.org/10.17816/JOWD66673-80
- ID: 7686
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Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women of reproductive age. It is known that kisspeptin stimulates activity of GnRH neurons and secretion of FSH and LH, thus disruption of interaction between kisspeptin and its receptor leads to anovulation. The aim of the study was to investigate the role kisspeptin in the pathogenesis of polycystic ovary syndrome. Materials and methods. The study included 14 patients with classic phenotype of PCOS and 11 healthy women of the control group. All the patients underwent laparoscopy and hysteroscopy with histological examination of ovarian tissue and endometrium. Determination of kisspeptin, FSH, LH, prolactin, AMH, estradiol, estrone, androgens (free testosterone and dehydroepiandrosterone sulfate) levels in peripheral blood in healthy women and patients with PCOS was performed by ELISA on the 2d and 8th days of menstrual cycle. Progesterone levels were investigated on the 18th-22d days of menstrual cycle. Expression of kisspeptin and its receptor in ovarian tissue and endometrium was estimated using immunohistochemical method. Results. Level of kisspeptin in peripheral blood of patients with PCOS tends to increase compared to its level in the control group, but the found difference was not reliable. Direct correlation between serum level of kisspeptin and levels of LH, free testosterone and DHEA-S was revealed in patients with PCOS. Immunohistochemical study in patients with PCOS showed a significant increase in the area of expression of КІЅЅ1 and KISS1R receptor in endometrium and in ovarian biopsies compared to these values in the control group. Conclusion. The obtained data show a definite role of kisspeptin in pathogenesis of polycystic ovary syndrome, but further research is needed.
作者简介
Maria Yarmolinskaya
Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
编辑信件的主要联系方式.
Email: m.yarmolinskaya@gmail.com
professor of RAS, head of department of endocrinology of reproduction, Doctor of medical sciences, head of center “Diagnostics and treatment of endometriosis”
俄罗斯联邦, Saint PetersburgNigar Ganbarli
Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: n-ganbarli@mail.ru
3rd year post-graduate student of Operative gynecology department
Saint PetersburgNatalia Tkachenko
Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: liberin@mail.ru
PhD, Head of the hormonal laboratory
俄罗斯联邦, Saint PetersburgVera Nikolaeva
Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: vin-161953@mail.ru
laboratoty assistant researcher of hormonal laboratory
Saint PetersburgGulrukhsor Tolibova
Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: gulyatolibova@mail.ru
PhD, MD
俄罗斯联邦, Saint PetersburgTatyana Tral
Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: TTG2008@bk.ru
MD, Pathologist. Head of Pathologist Laboratory, Department of Pathomorphology
俄罗斯联邦, Saint PetersburgViktor Rulev
Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: vrulev@mail.ru
Candidate of medical sciences, Researcher Endocrinology of Reproduction department
俄罗斯联邦, Saint PetersburgAnna Tsypurdeeva
Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: tsypurdeeva@mail.ru
Candidate of Medical Sciences, Head of Operative gynecology department
俄罗斯联邦, Saint Petersburg参考
- Адамян Л.В., Андреева Е.Н., Гаспарян С.А., и др. Синдром поликистозных яичников в репродуктивном возрасте (современные подходы к диагностике и лечению): клинические рекомендации (протокол лечения). – М., 2015. – 22 с. [Аdamyan LV, Аndreeva EN, Gasparyan SА, et al. Sindrom polikistoznykh yaichnikov v reproduktivnom vozraste (sovremennye podkhody k diagnostike i lecheniyu). Klini cheskie rekomendatsii (protokol lecheniya). Moscow; 2015. 22 p. (In Russ.)]
- Irwig M, Fraley G, Smith J, et al. Kisspeptin activation of gonadotropin releasing hormone neurons and regulation of KiSS-1 mRNA in the male rat. Neuroendocrinology. 2004;80:264-72. doi: 10.1159/000083140.
- Han S, Gottsch M, Lee K, et al. Activation of gonado tropin-r eleasing hormone neurons by kisspeptin as a neuroendocrine switch for the onset of puberty. The Journal of Neuroscience. 2005;25(49):11349-56. doi: 10.1523/jneurosci.3328-05.2005.
- Chan Y, Broder-Fingert S, Seminara S. Reproductive functions of kisspeptin and Gpr54 across the life cycle of mice and men. Peptides. 2009;30(1):42-8. doi: 10.1016/j.peptides.2008.06.015.
- Pielecka-Fortuna J, Chu Z, Moenter S. Kisspeptin Acts Directly and Indirectly to Increase Gonadotropin-Releasing Hormone Neuron Activity and Its Effects Are Modulated by Estradiol. Endocrinology. 2008;149(4):1979-86. doi: 10.1210/en.2007-1365.
- Chen X, Mo Y, Li L, et al. Increased plasma metastin levels in adolescent women with polycystic ovary syndrome. European Journal of Obstetrics Gynecology and Reproductive Biology. 2010;149(1):72-6. doi: 10.1016/j.ejogrb.2009.11.018.
- Jeon Y, Lee K, Jung J, et al. Kisspeptin, leptin and retinol-binding protein 4 in women with polycystic ovary syndrome. Gynecologic and Obstetric Investigation. 2013;75(4):268-74. doi: 10.1159/000350217.
- Yilmaz S, Kerimoglu O, Pekin A, et al. Metastin levels in relation with hormonal and metabolic profile in patients with polycystic ovary syndrome. European Journal of Obstetrics Gynecology and Reproductive Biology. 2014;180:56-60. doi: 10.1016/j.ejogrb.2014.06.004.
- Emekci Ozay O, Ozay AC, Acar B, et al. Role of kisspeptin in polycystic ovary syndrome (PCOS). Gynecol Endocrinol. 2016;32(9):718-22. doi: 10.3109/09513590.2016.1161019.
- Айламазян Э.К., Ярмолинская М.И., Ганбарли Н.Ф., и др. Роль метастина в патогенезе наружного генитального эндометриоза // Журнал акушерства и женских болезней. – 2017. – T. 66. – № 3. – С. 16–24. [Ailamazyan EK, Yarmolinskaya MI, Ganbarli NF, et al. The role of metastin in pathogenesis of genital endometriosis. Journal of Obstetrics and Women’s Diseases. 2017;66(3):16-24. doi: 10.17816/JOWD66316-24. (In Russ.)]
- Патент РФ на изобретение № 2602456/ 20.11.2016. Бюл. № 32. Самойлович Я.А., Потин В.В., Тарасова М.А., и др. Способ оценки активности ароматазы овариальных фолликулов. [Patent RUS No 2602456/ 20.11.2016. Byul. No 32. Samojlovich JA, Potin VV, Tarasova MA, et al. Sposob ocenki aktivnosti aromatazy ovarial’nyh follikulov. (In Russ.)]. Доступно по http://www.fips.ru/Archive4/PAT/2016FULL/2016.11.20/ Index_ru.htm.
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