电邮这篇文章 妊娠期糖尿病患者胎盘微核糖核酸（RNA）水平的评估
- 作者: Pakin V.S.1, Vashukova E.S.1, Kapustin R.V.1, Arzhanova O.N.1, Glotov A.S.1, Baranov V.S.1
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隶属关系:
- FSBSI “The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott”
- 期: 卷 66, 编号 3 (2017)
- 页面: 110-115
- 栏目: Articles
- URL: https://ogarev-online.ru/jowd/article/view/6844
- DOI: https://doi.org/10.17816/JOWD663110-115
- ID: 6844
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详细
新一代全基因组测序（NGS）方法对子痫前期胎盘微RNA水平的变化进行了比较分析，这取决于是否存在妊娠糖尿病（GDM）。GDM背景下发生子痫前期患者的his-miR-45a（p < 0.0001，FDR = 0.0050）
表达与未发生GDM的子痫前期患者相比，差异有统计学意义。子痫前期妊娠与GDM妊娠时胎盘中三种微RNA水平的变化：hsa-miR-4532（p < 0.0001，FDR = 0.0008）、hsa-miR-34c-5p（p < 0.000，
FDR = 0.0083）、hsa-miR-193b-5p（p < 0.0001，FDR = 0.0139）。研究表明GDM和子痫前期胎盘组织中微RNA含量的变化，使我们可以考虑将其作为子痫前期和GDM联合发展的潜在生物标志物。需要进一步的研究来阐明这些生物标志物在GDM和子痫前期发展的分子遗传学和表观遗传学机制中的作用。
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作者简介
Vladimir Pakin
FSBSI “The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott”
编辑信件的主要联系方式.
Email: pakins@list.ru
PhD student
俄罗斯联邦, 3, Mendeleevskaya line, Saint Petersburg, 199034Elena Vashukova
FSBSI “The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott”
Email: vi_lena@list.ru
scientist
俄罗斯联邦, 3, Mendeleevskaya line, Saint Petersburg, 199034Roman Kapustin
FSBSI “The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott”
Email: kapustin.roman@gmail.com
PhD
俄罗斯联邦, 3, Mendeleevskaya line, Saint Petersburg, 199034Olga Arzhanova
FSBSI “The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott”
Email: arjanova_olga@mail.ru
head of the Department Pathology of pregnancy, professor
俄罗斯联邦, 3, Mendeleevskaya line, Saint Petersburg, 199034Andrey Glotov
FSBSI “The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott”
Email: anglotov@mail.ru
senior researcher of the Laboratory prenatal diagnosis of hereditary and congenital diseases
俄罗斯联邦, 3, Mendeleevskaya line, Saint Petersburg, 199034Vladislav Baranov
FSBSI “The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott”
Email: baranov@vb2475.spb.ed
head of the Laboratory prenatal diagnosis of hereditary and congenital diseases, Corr. RAS, Professor
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