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Post a Comment Population genetic structure of HLA-G gene in North-west Region of Russian Federation
- Authors: Alenichev A.P.1, Nasykhova Y.A.2, Ivashchenko T.E.2, Baranov V.S.2
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Affiliations:
- Saint Petersburg State University
- D. O. Ott Research Institute of Obstetrics and Gynecology, RAMS
- Issue: Vol 12, No 2 (2014)
- Pages: 74-80
- Section: Articles
- URL: https://ogarev-online.ru/ecolgenet/article/view/2451
- DOI: https://doi.org/10.17816/ecogen12274-80
- ID: 2451
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Abstract
Background. HLA-G is a non-classical MHC class Ib molecule predominantly expressed in cytotrophoblasts and under pathological conditions also in chronically inflamed and in malignant tissues. Polymorphic sites present in coding and non-coding regions of the HLA-G gene may potentially affect all of these biological features. Materials and methods: Using the PCR method we have studied polymorphism of HLA G gene (alleles G*0101-G0107, -725C/G , 3741del/ins14.) in 118 people aged from 20 till 40 years of the North-West Region of Russia (St. Petersburg). Results: To determine the common alleles of the HLA-G gene the system of allele-specific PCR primers was elaborated. We have determined HLA-G allele distribution in North-west Region of Russian Federation. The minor allele frequencies varied in wide ranges - from 0 % to 39 %. The genetic distances among the Spanish, Chinese, Japanese, Danish, Indian, African Shona, Brazilian, Polish, German and North-west Region of Russian Federation were calculated. Conclusion: The evaluation of alleles rates in North-west of Russian Federation and in populations of other countries revealed the similarity in alleles G*0101-G0107 and polymorphism 3741del/ins14 distribution among the Danish, German and North-west Region populations.
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##article.viewOnOriginalSite##About the authors
Arseniy Pavlovich Alenichev
Saint Petersburg State University
Email: senyaa@list.ru
Student, Department of genetics and biotechnology
Yuliya Almazovna Nasykhova
D. O. Ott Research Institute of Obstetrics and Gynecology, RAMS
Email: yulnasa@gmail.com
Scientist (PhD), laboratory of prenatal diagnosis of congenital and inherited diseases
Tatyana Eduardovna Ivashchenko
D. O. Ott Research Institute of Obstetrics and Gynecology, RAMS
Email: tivashchenko2011@mail.ru
leading researcher (PhD, professor), laboratory of prenatal diagnosis of congenital and inherited diseases
Vladislav Sergeyevich Baranov
D. O. Ott Research Institute of Obstetrics and Gynecology, RAMS
Email: baranov@vb2475.spb.edu
head of the laboratory (MD, professor), laboratory of prenatal diagnosis of congenital and inherited diseases
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