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Post a Comment Pathogenetic associations of indicators of prenatal screening of the firsr trimester of pregnancy with fetal growth retardation
- Authors: Dektyarev A.A.1, Kudryavtseva E.V.2, Kovalev V.V.2
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Affiliations:
- Clinical Institute of Reproductive Medicine
- Ural State Medical University
- Issue: Vol 39, No 1 (2022)
- Pages: 11-20
- Section: Original studies
- URL: https://ogarev-online.ru/PMJ/article/view/83581
- DOI: https://doi.org/10.17816/pmj39111-20
- ID: 83581
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Abstract
Objective. To determine the relationship between the indicators of prenatal screening of the 1st trimester and the intrauterine growth retardation (IUGR).
Materials and methods. A prospective cohort study was carried out. Group 1 included 75 patients with fetal intrauterine growth retardation, group 2 – 414 women who gave birth to a live, full-term healthy baby with normal weight and height parameters. In all patients, the anamnestic parameters, indicators of PAPP-A, b-hCG, PlGF, thickness of the collar space and the pulsation index of the uterine arteries (PI UA) were compared.
Results. A number of significant differences in the anamnestic parameters were found between the groups. In group 1, multiparous women were met more often (16 % compared with 2.9% in group 2, p<0.001), women after сesarean section (13.3% and 5.6%, respectively, p=0.013), women with a history of spontaneous and artificial abortions (46.7% and 34.1 %, p=0.036). In addition, in group 1, patients were more likely to have uterine myoma – in 9.3 % versus 3.4% in group 2 (p=0.019). In group 1, during the first trimester screening, PAPP-A values were lower – 1.238 (0.68–2.05) IU/ml versus 2.25 (1.28–3.9) IU/ml in group 2 (p<0.001), and PlGF – 13.73 (10.22–19.09) IU/ml versus 17.19 (12.1–25.38) in group 2 (p=0.002). There were no significant differences in the level of b-hCG. The average pulsation index of the uterine arteries, on the contrary, in group 1 in the first trimester was higher than in group 2 – 1.73 (1.42–2.11) and 1.55 (1.32–1.85), respectively (p=0.024).
Conclusions. Thus, a number of anamnestic data and screening indicators for the first trimester have a statistically significant relationship with the presence of IUGR of the fetus; therefore, these indicators can be used to assess the risk of this pregnancy complication.
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##article.viewOnOriginalSite##About the authors
Andrew A. Dektyarev
Clinical Institute of Reproductive Medicine
Email: mygamesfirst@gmail.com
ORCID iD: 0000-0003-1124-1160
US physician
Russian Federation, EkaterinburgElena V. Kudryavtseva
Ural State Medical University
Author for correspondence.
Email: elenavladpopova@yandex.ru
ORCID iD: 0000-0003-2797-1926
SPIN-code: 7232-3743
MD, PhD, Associate Professor, Associate Professor of Department of Obstetrics and Gynecology
Russian Federation, EkaterinburgVladislav V. Kovalev
Ural State Medical University
Email: vvkovalev55@gmail.com
ORCID iD: 0000-0001-8640-8418
SPIN-code: 2061-0704
MD, PhD, Professor, Head of Department of Obstetrics and Gynecology, Transfusiology
Russian Federation, EkaterinburgReferences
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