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Post a Comment Study of wound-healing activity of sodium 2-(adamantane-1-yl)-2-hydrazino-5-phenyl-4-oxobutanoate
- Authors: Kuznetsov A.S.1, Pulina N.A.1, Chashchina S.V.1
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Affiliations:
- Perm State Pharmaceutical Academy
- Issue: Vol 38, No 6 (2021)
- Pages: 69-73
- Section: Clinical studies
- URL: https://ogarev-online.ru/PMJ/article/view/71977
- DOI: https://doi.org/10.17816/pmj38669-73
- ID: 71977
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Abstract
Objective. To study a wound-healing activity of the earlier synthesized ‘compound-leader” sodium 2- (adamantan-1-yl)-2-hydrazino-5-phenyl-4-oxobutenoate (1), as well as to establish the possibility of its practical application in the ointment dosage form.
Materials and methods. The “substance-leader” 1 was synthesized by the chemical methods described earlier. The experimental 5 % ointment composition based on an aqueous solution of sodium alginate was developed in compliance with the rules for preparing homogeneous ointments. Its effect on the healing of linear aseptic skin wounds in white rats was studied by the method of wound-tensiometry.
Results. The experimental 5 % ointment composition with compound 1 was found to significantly increase the scar tensile strength compared to control without treatment. The developed model ointment showed wound-healing activity comparable to that of the reference drug (Levomekol ointment).
Conclusions. The selected “substance-leader” 1 in the composition of a model 5 % hydrophilic ointment based on sodium alginate exhibits pronounced biological activity and is a candidate for further research as a potential pharmaceutical substance with complex wound-healing and anti-inflammatory property.
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##article.viewOnOriginalSite##About the authors
Alexander S. Kuznetsov
Perm State Pharmaceutical Academy
Author for correspondence.
Email: alexanderiv.88@mail.ru
Candidate pf Pharmaceutical Sciences, Associate Professor, Department of General and Organic Chemistry
Russian Federation, 614990 Perm, Polevaya st., 2.Natalya A. Pulina
Perm State Pharmaceutical Academy
Email: pulina-nata@mail.ru
Doctor of Pharmaceutical Science, Professor, Head of Department of Pharmaceutical Technology
Russian Federation, 614990, Perm, Polevaya st., 2Svetlana V. Chashchina
Perm State Pharmaceutical Academy
Email: physiology@list.ru
Candidate of Biological Sciences, Associate Professor, Department of Physiology
Russian Federation, 614990, Perm, Polevaya st., 2References
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