DIAGNOSTIC VALUE OF DAILY URINE METANEPHRIN TEST IN CHROMAFFIN TISSUE TUMORS

Aim. To assess the sensibility and specificity of daily urine metanephrin test in chromaffin tissue tumors. Materials and methods. The results of laboratory tests - daily urine metanephrins - were analyzed using immunoenzyme method in 64 patients with tumor diseases. Results. The method sensibility for pheochromocytoma was 76,2 %, for its malignant forms - 50 %; the method specificity was 65,1 %. There was established a significant rise in metanephrin level in the daily urine in case of pheochromocytoma as compared with the other adrenal tumors ( r = 0,38; p = 0,001), as well as in patients with a significant increase in arterial pressure, hypertensive crises, or persistent course of disease both in the group with pheochromocytomas and in the group with the other adrenal tumors ( r = 0,31; p = 0,1). The tendency to decrease in sensibility of daily urine metanephrins with growth in malignant tumor potential by PASS scale in case of chromaffin tissue tumors ( r = -0,32; p = 0,14) was noted. When analyzing the degree of elevation of daily urine metanephrins, significant dependence of pheochromocytoma available ( r = 0,49; p = 0,004) on matanephrin level ( r = 0,49; p = 0,004) was detected. The latter is reaching 100% in case of 4,6-fold increase in metanephrin and normetanephrin content.

Pheochromocytoma, metanephrins, adrenalectomy