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Post a Comment Influence of dental prostheses materials on the condition of oral mucosa local homeostasis
- Authors: Pervov Y.Y.1, Bocharov V.S.1, Kim A.R.1, Reva G.V.2
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Affiliations:
- Pacific State Medical University
- Far Eastern Federal University
- Issue: Vol 41, No 5 (2024)
- Pages: 5-18
- Section: Original studies
- URL: https://ogarev-online.ru/PMJ/article/view/271974
- DOI: https://doi.org/10.17816/pmj4155-18
- ID: 271974
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Abstract
Objective. To study the influence of base materials used in the manufacture of removable dentures on the immune homeostasis of the oral mucosa, and, as a consequence, on the clinical condition of the oral mucosa and periodontium of supporting teeth. To create fundamental principles for the development of a pathogenetically substantiated choice of basic dental materials of various chemical natures for removable prosthetics based on the analysis of the parameters of immune homeostasis of the oral mucosa.
Materials and methods. 154 patients aged 40 to 85 using dentures based on acrylic, polyurethane plastics and thermoplastics for 6 months, participated in the study. Indicators of immune homeostasis and the identified clinical manifestations of the influence of the prosthesis material such as chronic periodontitis and gingivitis were compared using the statistical method of conjugate multifield tables.
Results. The indicators CD4+/CD8+, CD11/CD303, CD68, CD204, CD163, Ki-67 phenotypic markers were determined in gingival biopsies of the prosthetic bed of patients using dentures based on acrylic, polyurethane and thermoplastic for 6 months. Analysis of the statistical significance of differences proved the influence of the prosthesis material on indicators of cellular immune homeostasis, with a shift of homeostasis towards the pro-inflammatory phenotype, and the suppression of the anti-inflammatory factor in circulating monocytes.
Conclusions. The study shows that, although each type of removable dentures has its own advantages and disadvantages, the response of the cellular immunity of the oral mucosa to polyurethane dentures is less than to acrylic and thermoplastic ones in relation to the control group. The use of polyurethane prostheses is reasonable as temporary ones during the healing stage of surgical interventions in the oral cavity, in particular tooth extraction and implantation. This type of prosthesis can be recommended as a permanent one for patients with a severe allergic reaction, especially to polymer compounds and dyes.
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##article.viewOnOriginalSite##About the authors
Yu. Y. Pervov
Pacific State Medical University
Email: pervov73@mail.ru
ORCID iD: 0000-0001-8505-7062
SPIN-code: 1850-2689
DSc (Medicine), Associate Professor, Head of the Institute of Dentistry
Russian Federation, VladivostokV. S. Bocharov
Pacific State Medical University
Author for correspondence.
Email: vskadar@mail.ru
ORCID iD: 0009-0004-2063-7428
Assistant of the Institute of Dentistry
Russian Federation, VladivostokA. R. Kim
Pacific State Medical University
Email: grx_125@mail.ru
ORCID iD: 0009-0006-2911-9883
Assistant of the Institute of Dentistry
Russian Federation, VladivostokGalina V. Reva
Far Eastern Federal University
Email: revagal@yandex.ru
DSc (Medicine), Professor, Professor of the Department of Fundamental Medicine
Russian Federation, VladivostokReferences
- Дзалаева Ф.К., Чикунов С.О., Утюж А.С., Михайлова М.В., Будунова М.К. Изучение потребностей населения г. Москвы в ортопедическом лечении и реабилитации пациентов с необходимостью тотальных реставраций зубных рядов. Институт стоматологии 2020; 87 (2): 12–15 / Dzalaeva F.K., Chikunov S.O., Utyuzh A.S., Mihajlova M.V., Budunova M.K. Studying the needs of the population of Moscow in prosthetic treatment and rehabilitation of patients with the need for total restorations of dentition. Institut stomatologii 2020; 87 (2): 12–15 (in Russian).
- Chen Y., Du J., Liu Y., Luo Z. et al. T cells in oral tissue immune surveillance and pathology. Frontiers in Immunology. Sec. T Cell Biology 2022; 13. doi: 10.3389/fimmu.2022.1050030
- Кочурова Е.В., Николенко В.Н., Гаврюшова Л.В., Муханов А.А. Влияние современных стоматологических материалов на слизистую оболочку полости рта. Стоматология 2020; 99 (2): 110–113. doi: 10.17116/stomat202099021110 / Kochurova E.V., Nikolenko V.N., Gavrushova L.V., Mukhanov A.A. Influence of modern dental materials on the oral mucosa. Journal of Stomatology 2020; 99 (2): 110–113 (in Russian). doi: 10.17116/stomat202099021110
- Hovav A.H., Wilharm A., Barel O., Prinz I. Development and function of T cells in the oral mucosa. J Dent Res 2020; 99: 498–505. doi: 10.1177/0022034520908839
- Чурина Е.Г., Попова А.В., Уразова О.И., Патышева М.Р., Колобовникова Ю.В., Чумакова С.П. Экспрессия скавенджер-рецепторов CD163, CD204 и CD206 на макрофагах у больных туберкулезом легких. Бюллетень сибирской медицины 2022; 21 (4): 140–149. doi: 10.20538/1682-0363-2022-4-140-149 / Churina E.G., Popova A.V., Urazova O.I., Patysheva M.R., Kolobovnikova Ju.V., Chumakova S.P. Expression of scavenger receptors CD163, CD204, and CD206 on macrophages in patients with pulmonary tuberculosis. Bulletin of Siberian Medicine 2022; 21 (4): 140–149 (in Russian). doi: 10.20538/1682-0363-2022-4-140-149
- Ковалева О.В., Рашидова М.А., Самойлова Д.В. и др. Прогностическая значимость экспрессии CD204 и IDO1 в опухолях пищевода. Успехи молекулярной онкологии 2021; 8 (2): 40–6. doi: 10.17650/2313-805X-2021-8-2-40-46 / Kovaleva O.V., Rashidova M.A., Mochalnikova V.V. et al. Prognostic significance of CD204 and IDO1 expression in esophageal tumors. Uspekhi molekulyarnoy onkologii = Advances in Molecular Oncology 2021; 8 (2): 40–6 (in Russian). doi: 10.17650/2313-805X-2021-8-2-40-46
- Guo J., Xu R. et al. Association between the systemic immune inflammation index and periodontitis: Journal of Translational Medicine. 2024; 22: Article number: 96 (2024). doi: 10.1186/s12967-024-04888-3
- Сотникова Н.Ю., Фарзалиева А.В., Борзова Н.Ю., Воронин Д.Н., Крошкина Н.В. Характеристика дифференцировки моноцитов и экспрессии CD163 у женщин с угрожающим ранним выкидышем. Иммунология 2022; 43 (6): 714–721. doi: 10.33029/0206-4952-2021-42-6-714-721 / Sotnikova N.Yu., Farzalieva A.V., Borzova N.Yu., Voronin D.N., Kroshkina N.V. Characteristics of monocyte differentiation and CD163 expression in women with pointed early mission. Immunologiya 2022; 43 (6): 714–21 (in Russian). doi: 10.33029/0206-4952-2021-42-6-714-721
- Wolf A.A., Yáñez A., Barman P.K., Goodridge H.S. The ontogeny of monocyte subsets. Frontiers in Immunology. Sec. Antigen Presenting Cell Biology 2019; 10: 1642. doi: 10.3389/fimmu.2019.01642
- Zhuang Z., Yoshizawa-Smith S., Glowacki A., Maltos K., Pacheco C., Shehabeldin M. Induction of M2 Macrophages prevents bone loss in murine periodontitis models. J Dent Res. 2019; 98: 200–8. doi: 10.1177/0022034518805984
- Kuroishi T., Танака Y., Furukawa M., Nochi T., Sugawara S. Differential expression of CD11c defines two types of tissue-resident macrophages with different origins in steady-state salivary glands. PubMed 2022; 12 (1): 931. doi: 10.1038/s41598-022-04941-5
- Almubarak A., Tanagala K., Papapanou P. et al. Almubarak A, Tanagala KKK, Papapanou PN, Lalla E and Momen-Heravi F (2020) Disruption of Monocyte and Macrophage Homeostasis in Periodontitis. Frontiers in Immunology. Sec. Molecular Innate Immunity 2020; 11. doi: 10.3389/fimmu.2020.00330
- Ковалева О.В., Рашидова М.А., Подлесная П.А. и др. Прогностическая значимость комплексной оценки экспрессии Ki-67, фактора некроза опухоли , CD20 и CD31 при немелкоклеточном раке легкого. Успехи молекулярной онкологии 2021; 8 (4): 67–74. doi: 10.17650/2313-805X-2021-8-4-67-74 / Kovaleva O.V., Rashidova M.A., Podlesnaya P.A., Samoilova D.V., Mochalnikova V.V., Gratchev A.N. Prognostic value of complex assessment of Ki-67, tumor necrosis factor , CD20 and CD31 expression in non-small cell lung cancer. Uspekhi molekulyarnoj onkologii 2021; 8 (4): 67–74 (in Russian). doi: 10.17650/2313-805X-2021-8-4-67-74
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