Correlation between severity of health status in extremely premature newborns on third day of life and clinicolaboratory indices

Aim. To detect the correlation between the severity of health status in extremely premature newborns and the changes in clinical and laboratory indices.

Materials and methods. The study included small premature newborn infants with extremely low body mass and very low-birth-weight infants with clinical picture of respiratory distress syndrome. To carry out the study, patients were divided into 2 groups depending on the health status severity index on the third day of life using NEOMOD scale. Group I enclosed infants with health status severity on the third day of life from 0 to 2 scores, group II – patients with health status severity on the third day from 3 and more scores by NEOMOD scale.

Results. The patients with more severe health status according to NEOMOD scale had lower blood erythrocyte index on the first day of life as compared to the patients with less severe health status (U = 64; р = 0.034). There was revealed a direct relationship between health status severity on the third day and health status severity on the first day (U = 56.5; р = 0.014), stab neutrophil number (U = 57; р = 0.016) and neutrophil nuclear shift index (NNSI) (U = 61; p = 0.025) on the twenty eighth day.

Conclusions. The lower number of erythrocyte on the first day of life is interconnected with more severe health status on the third day of life. The initial severity of respiratory failure in case of respiratory distress syndrome influences the duration of infectious processes, in particular, pneumonia with high indices of infectious markers.