Morphofunctional parameters of the immune system of chickens after dissemination of bacteria Pseudomonas aeruginosa

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Abstract

Infectious diseases caused by ubiquitous bacteria with variability of virulence factors and multiple antibiotic resistance reliably often represent the structure of the general pathology of poultry. The aim of the study was to analyze dynamics of morph functional parameters of immune system of chickens in experimental pseudomonas infection. The initiation, development, and outcome of the experimental infectious process were considered using bacteriological and immunological methods with vital dye. Dissemination of P. aeruginosa bacteria revealed significant increase in extravasation of lung blood vessels, signs of hemodynamic disorders, and development of dystrophic and compensatory-­adaptive processes. Pathogenic mechanisms are mediated by the dynamics of changes in reticuloendothelial and lymph epithelial systems: accidental transformation of thymus, atrophy of bursa of Fabricius, hyperplasia of esophageal and cecum lymphoid follicles, Meckel’s diverticulum, and spleen.

About the authors

Ekaterina M. Lenchenko

Russian Biotechnological University (BIOTECH University)

Author for correspondence.
Email: lenchenko.ekaterina@yandex.ru
ORCID iD: 0000-0003-2576-2020
SPIN-code: 9417-0889

Doctor of Veterinary Sciences, Professor, Department of Veterinary Medicine, Institute of Veterinary Medicine, Veterinary and Sanitary Expertise and Agricultural Safety

11 Volokolamskoe highway, Moscow, 125080, Russian Federation

Galina S. Tolmacheva

Gorbatov Federal Research Center for Food Systems

Email: tgs2991@yandex.ru
ORCID iD: 0000-0001-9937-320X
SPIN-code: 6909-2048

Research engineer

26 Talalikhina st., Moscow, 109316, Russian Federation

Evgeny V. Kulikov

RUDN University

Email: kulikov-ev@rudn.ru
ORCID iD: 0000-0001-6936-2163
SPIN-code: 6199-2479

Candidate of Biological Sciences, Associate Professor, Department of Veterinary Medicine

6 Miklukho-Maklaya st., Moscow, 117198, Russian Federation

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