Analysis of pathogenetic manifestation of decompensated intestinal dysbacteriosis in cats

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Abstract

Despite the creation of more and more new generations of antibacterial agents, the correction of intestinal dysbiosis in animals currently remains one of the most complex and urgent problems in clinical veterinary medicine. The article presents an analysis of the pathogenetic manifestation (microbial background, hematological analytes) in decompensated intestinal dysbacteriosis in domestic cats in the dynamics of its correction. The aim of the study was to study the comparative effectiveness of various pharmacotherapy regimens for decompensated intestinal dysbacteriosis in cats. The data shows that when correcting decompensated intestinal dysbacteriosis in domestic cats, the most rational treatment regimen is the complex use of Lactobifadol probiotic (contains at least 1.0 × 106 CFU/g of lactic acid bacteria Lactobacillus acidophilus LG1-DEP-VGIKI and 8.0 × 107 CFU/g of bifidobacteria Bifidobacterium adolescentis B-1-DEP-VGNKI), Vetelact prebiotic (contains lactulose - not less than 50 %), Azoksivet immunomodulator (contains 1.5 mg of azoximer bromide in 1 ml), as well as infusion therapy (intravenous drip injection of 10 ml/kg of 0.9 % sodium chloride solution; 10 ml/kg of 5 % glucose solution; 5 ml/kg of rheosorbelact and 2.5 ml/kg of refortan). This was confirmed by the results of pathogenetic picture (analysis of the microbial background and individual hematological analytes), in the dynamics of pharmacotherapy, namely before the start of correction, as well as on days 7 and 14. The improvement of diagnostic approaches and methods for correcting the most severe degree of intestinal dysbacteriosis (the stage of decompensation) creates prerequisites for the future study of dysbiotic disorders of the intestinal tract in other animal species, considering the severity of its manifestation.

About the authors

Evgeny V. Kulikov

RUDN University

Email: eugeny1978@list.ru
ORCID iD: 0000-0001-6936-2163

Candidate of Biological Sciences, Associate Professor, Agrarian and Technological Institute

6 Miklukho-Maklaya st., Moscow, 117198, Russian Federation

Nikolai V. Babichev

RUDN University

Email: babichev-nv@rudn.ru
ORCID iD: 0000-0001-8444-8600

Candidate of Biological Sciences, Associate Professor, Agrarian and Technological Institute

6 Miklukho-Maklaya st., Moscow, 117198, Russian Federation

Alena I. Telezhenkova

RUDN University

Email: telezhenkova-ai@rudn.ru

assistant, Department of Veterinary Medicine, Agrarian and Technological Institute

6 Miklukho-Maklaya st., Moscow, 117198, Russian Federation

Nikolai S. Bugrov

RUDN University

Email: bugr24-8@mail.ru
ORCID iD: 0000-0002-4116-0620

PhD student, Department of Veterinary Medicine, Agrarian and Technological Institute

6 Miklukho-Maklaya st., Moscow, 117198, Russian Federation

Pavel A. Rudenko

RUDN University; Skryabin Institute of Biochemistry and Physiology of Microorganisms of the Russian Academy of Sciences

Author for correspondence.
Email: pavelrudenko76@yandex.ru
ORCID iD: 0000-0002-0418-9918

Doctor of Veterinary Sciences, Leading Researcher, Laboratory of Cell Surface Biochemistry of Microorganisms, Skryabin Institute of Biochemistry and Physiology of Microorganisms of the Russian Academy of Sciences Associate Professor, Department of Veterinary Medicine, Agrarian and Technological Institute, Peoples’ Friendship University of Russia (RUDN University)

5 Nauki av., Pushchino, Moscow region, 142290, Russian Federation; 6 Miklukho-Maklaya st., Moscow, 117198, Russian Federation

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