Vitamin and mineral status correction in pregnant women with a high risk of macrosomia

Purpose. Optimizing the correction of vitamin and mineral status in pregnant women with a high risk of macrosomia. Patients. 1308 female patients were examined at 23–24 weeks of pregnancy. Increased risk of macrosomia was diagnosed in 527 pregnant women. Two groups were formed: first group, consisting of 280 women who were not taking any vitamin-mineral complexes (VMC) at the diagnosis time, and the 2nd group, consisting of 247 women receiving VMCs since the establishment of pregnancy. Methods. Quantitative determination of zinc (Zn) was performed by mass spectrometry, whereas vitamins such as A, E – by means of the high performance liquid chromatography (HPLC), and vitamin C – using the Farmer-Abt method. For early macrosomia prediction the «method of predicting birth of a large fetus» was used (patent number 2,428,118 as of 18.01.2010). Results. In the first group at 23–24 weeks' gestation revealed the following changes in element reduction: in Zn provision in 72,5% of the cases, in B12 vitamin in 70,3%, in B1 vitamin in 65,8%, in B9 vitamin – in 63,9%, and vitamin C – in 54,6%. Upon VMC prescription to the group of pregnant women from 24 weeks of pregnancy up to the delivery the normal physiological levels of Zn, at the lower boundary level of vitamins B1, B12, B6, B9 are not restored. In pregnant women who received the VMC Alphabet Mommy's health a statistically significantly higher provision of Zn and vitamin B9, compared to a group of pregnant women who received single-pill VMC was noted. Conclusion. In the event of receiving VMC at 23–24 weeks of pregnancy the VMC produced with interactions should be preferred in order to increase the vitamin B9 and Zn provision.

vitamin-mineral complex, interaction, macrosomia, zinc, folic acid