Challenges with the differential diagnosis of progressive supranuclear palsy and Parkinson’s disease
- Authors: Magzhanov R.V.1, Davletova A.I.1, Ibatullin R.А.2, Tunik V.F.2, Idrisova R.F.2, Bakhtiyarova K.Z.2
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Affiliations:
- Bashkir State Medical University
- Kuvatov Republican Clinical Hospital
- Issue: Vol 10, No 4 (2016)
- Pages: 58-61
- Section: Clinical analysis
- URL: https://ogarev-online.ru/2075-5473/article/view/124698
- DOI: https://doi.org/10.17816/psaic22
- ID: 124698
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Abstract
Progressive supranuclear palsy (PSP) is a severe old-age neurodegenerative disease that is characterized by pronounced clinical polymorphism and has different phenotypes. Practical differential diagnosis of PSP and Parkinson’s disease (PD) presents significant challenge, especially in onset of the disease. We report an atypical case of PSP characterized by symmetric levodopa-resistant parkinsonian syndrome, early postural instability, supranuclear oculomotor disorders (vertical gaze palsy), MR signs of midbrain atrophy, and a number of overlapping clinical symptoms similar with the manifestations of PD. A detailed algorithm of differential diagnosis of PSP and PD as well as a more adequate diagnostic formulation are proposed for this and similar cases of neurodegenerative pathology.
About the authors
R. V. Magzhanov
Bashkir State Medical University
Email: angelika7d@mail.ru
Russian Federation, Ufa
Angelika I. Davletova
Bashkir State Medical University
Author for correspondence.
Email: angelika7d@mail.ru
Russian Federation, Ufa
R. А. Ibatullin
Kuvatov Republican Clinical Hospital
Email: angelika7d@mail.ru
Russian Federation, Ufa
V. F. Tunik
Kuvatov Republican Clinical Hospital
Email: angelika7d@mail.ru
Russian Federation, Ufa
R. F. Idrisova
Kuvatov Republican Clinical Hospital
Email: angelika7d@mail.ru
Russian Federation, Ufa
K. Z. Bakhtiyarova
Kuvatov Republican Clinical Hospital
Email: angelika7d@mail.ru
Russian Federation, Ufa
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