We present results of clinical and electrophysological analysis of 34 patients with recurrent facial neuropathy (rFN). Its frequency (10.9%) among all forms of facial neuropathies was determined, and clinical and EMG characteristics, as well as possible risk factors, were described. A separate group of familial rFN was identified, and these patients exhibited high percentage of subclinical peripheral nerve involvement. Positive family history, presence of relapses and electroneurographic features allowed to suspect hereditary neuropathy with liability to pressure palsy in these patients. However, molecular analysis of the РМР22 gene failed to reveal a typical gene deletion. These results leave open the question about etiology and pathophysiologic mechanisms of rFN and warrant further studies of genetic defect underlying a familial form of rFN.
Recurrent facial nerve neuropathies: clinical, electrophysiological and molecular analysis
- Authors: Savitskaya N.G.1, Nikitin S.S.2, Illarioshkin S.N.1, Klushnikov S.A.1, Ivanova-Smolenskaya I.A.1, Ostaphyichuk A.V.3
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Affiliations:
- Research Center of Neurology, Russian Academy of Medical Sciences
- Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences (Moscow)
- Central military hospital № 5, Ministry of Defense of Russian Federation (Кrasnogorsk)
- Issue: Vol 5, No 4 (2011)
- Pages: 29-32
- Section: Original articles
- URL: https://ogarev-online.ru/2075-5473/article/view/124505
- DOI: https://doi.org/10.17816/psaic291
- ID: 124505
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About the authors
N. G. Savitskaya
Research Center of Neurology, Russian Academy of Medical Sciences
Author for correspondence.
Email: platonova@neurology.ru
Russian Federation
S. S. Nikitin
Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences (Moscow)
Email: platonova@neurology.ru
Russian Federation
S. N. Illarioshkin
Research Center of Neurology, Russian Academy of Medical Sciences
Email: platonova@neurology.ru
Russian Federation
S. A. Klushnikov
Research Center of Neurology, Russian Academy of Medical Sciences
Email: platonova@neurology.ru
Russian Federation
I. A. Ivanova-Smolenskaya
Research Center of Neurology, Russian Academy of Medical Sciences
Email: platonova@neurology.ru
Russian Federation
A. V. Ostaphyichuk
Central military hospital № 5, Ministry of Defense of Russian Federation (Кrasnogorsk)
Email: platonova@neurology.ru
Russian Federation
References
- Завалишин И.А., Переседова А.В. Лицевая невропатия. Росс. стоматол. журн. 2001; 1: 21–25.
- Лобзин В.С., Цацкина Н.Д. Наследственно-семейные формы невропатии лицевого нерва. Журн. невропатол. и психиатрии им. С.С. Корсакова 1988; 11: 7–10.
- Савицкая Н.Г., Никитин С.С., Иллариошкин С.С. и др. Клинико- электрофизиологический анализ семейных случаев наследственной невропатии с предрасположенностью к параличам от сдавления. Неврол. вестн. 2001; 3–4: 5–9.
- Bladdom R.L. Familial carpal tunnel syndrome in three generations of black family. Am. J. Phys. Med. 1985; 64: 227–234.
- Cruz-Martinez A., Arpa J. Pediatric bilateral carpal tunnel syndrome as first manifestation of hereditary neuropathy with liability to pressure palsies (HNPP). Eur. J. Neurol. 1999; 5: 316–317.
- Davies D.M. Reccurent peripheral nerve palsies in a family. Lancet 1954; 2: 266–268.
- Donofrio P.D., Albers J.W. Polyneuropathy: classification by nerve conduction studies and electromyography. Muscle Nerve 1990; 13: 889–903.
- Doshi J., Irving R. Recurrent facial nerve palsy: the role of surgery. J. Laryngol. Otol. 2010; 124: 1202–1204.
- Dyck P.J., Chance P.F., Lebo R.V. et al. Hereditary motor and sensory neuropathies. In: Peripheral neuropathy, 3rd ed. Philadelphia: Saunders, 1993: 1094–1136.
- England J.D. Entrapment neuropathies. Curr. Opin. Neurol. 1999; 12: 597–602.
- Gossett J.G., Chance P.F. Is there a familial carpal tunnel syndrome? An evaluation and literature review. Muscle Nerve 1998; 21: 1533–1536.
- Grosheva M., Wittekindt C., Guntinas-Lichius O. Prognostic value of electroneurography and electromyography in facial palsy. Laryngoscope 2008; 118: 394–397.
- Keller M.P., Chance P.F. Inherited neuropathies: from gene to disease. Brain Pathol. 1999; 9: 327–341.
- Lormeau G., Reignier A., Soubeyrand L. et al. Reccurent paralysis disclosing Lyme disease. Press Ned. 1994; 23: 1357–1359.
- Ludin H.P. Elecromyography in practice. Stuttgart, 1980.
- Lupski J.R., de Oca-Luna R.M., Slaugenhaupt S. et al. DNA duplication associated with Charcot-Marie-Tooth disease type 1A. Cell 1991; 66: 219–232.
- Mouton P., Tardieu S., Gouider R. et al. Spectrum of clinical and electrophysiologic features in HNPP patients with the 17p11.2 deletion. Neurology 1999; 52: 1440–1446.
- Nelis E., Van Brockhoven C., De Jonghe P. et al. Estimation of the mutation frequencies in Charcot-Мarie-Tooth disease type 1 and hereditary neuropathy with liability to pressure palsies: European collaborative study. Eur. J. Hum. Genet. 1996; 4: 25–33.
- Ngow H.A., Wan Khairina W.M., Hamidon B.B. Recurrent Bell’s palsy in a young woman. Singapore Med. J. 2008; 49: 278–280.
- Qin D., Ouyang Z., Luo W. Familial recurrent Bell’s palsy. Neurol India 2009; 57: 783–784.
- Rosler К.М., Magistris M.R., Glocker F.X. et al. Electrophysiological characteristics of lesions in facial palsies of different etiologies. A study using electrical and magnetic stimulation techniques. Electroenceph. Clin. Neurophysiol. 1995; 97: 355–368.
- Stewart J.D. Focal peripheral neuropathies. New York: Raven, 1993.
- Thomas P.K., Ochoa J. Symptomatology and differential diagnosis of peripheral neuropathy. In: Dyck P.J., Thomas P.K. (eds.) Peripheral neuropathy. Philadelphia: Saunders, 1993: 749–774.
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