A case of severe generalized myasthenia with late onset and predominant lesion of bulbar muscles: the case report and review
- Authors: Serdyuk A.V1, Kovrazhkina E.A1, Vyatkina N.V2
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Affiliations:
- N.I.Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation
- City Clinical Hospital №31 of the Department of Health of Moscow
- Issue: Vol 20, No 2 (2018)
- Pages: 59-62
- Section: Articles
- URL: https://ogarev-online.ru/2075-1753/article/view/95016
- DOI: https://doi.org/10.26442/2075-1753_2018.2.59-62
- ID: 95016
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Abstract
Myasthenia gravis according to modern concepts is a heterogeneous group of autoimmune pathology with a postsynaptic neuromuscular transmission defectsts and can be classified by the prevalence of the lesion, the detection of specific antibodies, the age at onset of the disease, the presence of thymus pathology. Such a clinico-pathogenetic heterogencity creates difficulties in the diagnostics and treatment of the disease. With late (over 50 years) myasthenia gravis debilily, the disease often has flow characteristics: a predominat lesion of bulbar musculature, a severe progressive course, a lack of proper effect from the therapy. If in patients with myastenia gravis of older age there is vascular load, then it is often mistakenly diagnosed with cerebral stroke. Presented case severe generalized myasthenia gravis with bulbar syndrome in a patient of 60 years old, shows the features of the cours of this disease with late debute.
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##article.viewOnOriginalSite##About the authors
A. V Serdyuk
N.I.Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation
Email: aserdyuk@gmail.com
канд. мед. наук, ассистент каф. неврологии, нейрохирургии и мед. генетики 117997, Russian Federation, Moscow, ul. Ostrovitianova, d. 1
E. A Kovrazhkina
N.I.Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federationканд. мед. наук, ст. науч. сотр. НИИ цереброваскулярной патологии и инсульта 117997, Russian Federation, Moscow, ul. Ostrovitianova, d. 1
N. V Vyatkina
City Clinical Hospital №31 of the Department of Health of Moscowврач-невролог 119415, Russian Federation, Moscow, ul. Lobachevskogo, d. 42
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