Influence of individual and subpopulation factors on the concentration of major and trace elements in saliva

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BACKGROUND: The determination of the major and trace element composition of saliva could be a promising approach for non-invasive health monitoring. Such investigations are constrained, nevertheless, by the potential impact of several variables on the concentration of the elements.

AIM: To study the influence of individual and subpopulation factors of donors on the concentration of some major and trace elements in saliva.

MATERIALS AND METHODS: The results of the determination of elements concentration (Ag, Al, Ca, Cd, Cr, Cu, Fe, Mg, Mn, P, Pb, Si, Ti, Zn) in the whole saliva of 60 donors by direct (without digestion) analysis by arc atomic emission spectrometry using the dry residue technique are presented.

RESULTS: Distribution of concentrations in the sample for Al, Cr, Cu, Fe, Mg, Mn, Si, Ti, and Zn showed a lognormal law; thus, the geometric mean or median is preferable as an indicator reflecting the average value. The distribution of Ca and P concentrations obeys the normal law. The concentration of Si and Ti is lower in the saliva of young men compared with women; the opposite pattern is observed for Mn. The mean Ag concentration in saliva is higher in the group of smokers than in non-smokers. Increase in the number of teeth affected by caries was correlated with an increase in concentrations of Cu, Al, and Zn in the saliva. For several analytes, interelement correlations were revealed, in particular, between the concentrations of Ca and P.

CONCLUSION: The study of such factors of influence enables clinicians to determine the normal concentration ranges of major and trace elements in each specific clinical case with greater accuracy.

作者简介

Sergey Savinov

Saint Petersburg State University

编辑信件的主要联系方式.
Email: s.s.savinov@spbu.ru
ORCID iD: 0000-0002-7214-5917
SPIN 代码: 2737-4140

Cand. Sci. (Chem.)

俄罗斯联邦, Saint Petersburg

Anatoly Drobyshev

Saint Petersburg State University

Email: drobyshevai@mail.ru
ORCID iD: 0000-0002-9174-2055
SPIN 代码: 3394-5218

Dr. Sci. (Phys.-Math.), Professor

俄罗斯联邦, Saint Petersburg

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2. Fig. 1. Distribution of the logarithm of Si concentration in saliva in the general group of donors (n=60, a), in the subgroup of young men (n=25, b) and women (n=35, c).

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