Отправить статью по E-mail Effects of some 5-anilino-1,2,4-thiadiazole derivatives onto leukemic cells
- Авторы: Orlova M.A.1,2, Trofimova T.P.1,2, Proshin A.N.3, Orlov A.P.1
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Учреждения:
- Department of Chemistry, M. V. Lomonosov Moscow State University
- Department of Biochemistry and Pharmacology, D. Rogachev Federal Clinical Center of Pediatric Hematology, Oncology and Immunology
- Department of Organic Synthesis, Institute of Physiological Active Compounds of Russian Academy of Sciences
- Выпуск: Том 66, № 5 (2017)
- Страницы: 932-934
- Раздел: Brief Communications
- URL: https://ogarev-online.ru/1066-5285/article/view/240654
- DOI: https://doi.org/10.1007/s11172-017-1833-5
- ID: 240654
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Аннотация
The antileukemic activities of some thiadiazole derivatives in the forms of hydrochlorides and salicylates have been determined. The insertion of salicylate ion in the compound increases the therapeutic index, mainly due to the reduction of cytotoxicity against healthy cells.
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Об авторах
M. Orlova
Department of Chemistry, M. V. Lomonosov Moscow State University; Department of Biochemistry and Pharmacology, D. Rogachev Federal Clinical Center of Pediatric Hematology, Oncology and Immunology
Автор, ответственный за переписку.
Email: Orlova.radiochim@mail.ru
Россия, Bld. 3, 1 Leninskie Gory, Moscow, 119992; 1 ul. Samora Mashel, Moscow, 117997
T. Trofimova
Department of Chemistry, M. V. Lomonosov Moscow State University; Department of Biochemistry and Pharmacology, D. Rogachev Federal Clinical Center of Pediatric Hematology, Oncology and Immunology
Email: Orlova.radiochim@mail.ru
Россия, Bld. 3, 1 Leninskie Gory, Moscow, 119992; 1 ul. Samora Mashel, Moscow, 117997
A. Proshin
Department of Organic Synthesis, Institute of Physiological Active Compounds of Russian Academy of Sciences
Email: Orlova.radiochim@mail.ru
Россия, 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432
A. Orlov
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: Orlova.radiochim@mail.ru
Россия, Bld. 3, 1 Leninskie Gory, Moscow, 119992
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