Effects of some 5-anilino-1,2,4-thiadiazole derivatives onto leukemic cells


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Abstract

The antileukemic activities of some thiadiazole derivatives in the forms of hydrochlorides and salicylates have been determined. The insertion of salicylate ion in the compound increases the therapeutic index, mainly due to the reduction of cytotoxicity against healthy cells.

About the authors

M. A. Orlova

Department of Chemistry, M. V. Lomonosov Moscow State University; Department of Biochemistry and Pharmacology, D. Rogachev Federal Clinical Center of Pediatric Hematology, Oncology and Immunology

Author for correspondence.
Email: Orlova.radiochim@mail.ru
Russian Federation, Bld. 3, 1 Leninskie Gory, Moscow, 119992; 1 ul. Samora Mashel, Moscow, 117997

T. P. Trofimova

Department of Chemistry, M. V. Lomonosov Moscow State University; Department of Biochemistry and Pharmacology, D. Rogachev Federal Clinical Center of Pediatric Hematology, Oncology and Immunology

Email: Orlova.radiochim@mail.ru
Russian Federation, Bld. 3, 1 Leninskie Gory, Moscow, 119992; 1 ul. Samora Mashel, Moscow, 117997

A. N. Proshin

Department of Organic Synthesis, Institute of Physiological Active Compounds of Russian Academy of Sciences

Email: Orlova.radiochim@mail.ru
Russian Federation, 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432

A. P. Orlov

Department of Chemistry, M. V. Lomonosov Moscow State University

Email: Orlova.radiochim@mail.ru
Russian Federation, Bld. 3, 1 Leninskie Gory, Moscow, 119992

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