Hydroxamic acids: synthesis and adjuvant activity in combinatorial anticancer therapy
- 作者: Fedorov B.S.1, Fadeev M.A.1, Eremeev A.B.1, Konovalova N.P.1, Bogdanov G.N.1, Tatyanenko L.V.1, Sashenkova T.E.1, Mishchenko D.V.1
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隶属关系:
- Institute of Problems of Chemical Physics, Russian Academy of Sciences
- 期: 卷 65, 编号 3 (2016)
- 页面: 801-805
- 栏目: Full Articles
- URL: https://ogarev-online.ru/1066-5285/article/view/237682
- DOI: https://doi.org/10.1007/s11172-016-1377-0
- ID: 237682
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详细
Monoand disubstituted N-hydroxyamides of dicarboxylic acids were prepared by reaction of dicarboxylic acids or acid anhydrides with hydroxylamine. The use of these compounds in combinatorial cytostatic therapy of implanted tumors with cisplatin or cyclophosphamide totally inhibits metastasis formation in B16 melanoma and Lewis lung carcinoma, and resulted in 100% survival of leukemic animals.
作者简介
B. Fedorov
Institute of Problems of Chemical Physics, Russian Academy of Sciences
编辑信件的主要联系方式.
Email: boris-45@inbox.ru
俄罗斯联邦, 1 prosp. Akad. N. N. Semenova, Chernogolovka, Moscow Region, 142432
M. Fadeev
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: boris-45@inbox.ru
俄罗斯联邦, 1 prosp. Akad. N. N. Semenova, Chernogolovka, Moscow Region, 142432
A. Eremeev
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: boris-45@inbox.ru
俄罗斯联邦, 1 prosp. Akad. N. N. Semenova, Chernogolovka, Moscow Region, 142432
N. Konovalova
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: boris-45@inbox.ru
俄罗斯联邦, 1 prosp. Akad. N. N. Semenova, Chernogolovka, Moscow Region, 142432
G. Bogdanov
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: boris-45@inbox.ru
俄罗斯联邦, 1 prosp. Akad. N. N. Semenova, Chernogolovka, Moscow Region, 142432
L. Tatyanenko
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: boris-45@inbox.ru
俄罗斯联邦, 1 prosp. Akad. N. N. Semenova, Chernogolovka, Moscow Region, 142432
T. Sashenkova
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: boris-45@inbox.ru
俄罗斯联邦, 1 prosp. Akad. N. N. Semenova, Chernogolovka, Moscow Region, 142432
D. Mishchenko
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: boris-45@inbox.ru
俄罗斯联邦, 1 prosp. Akad. N. N. Semenova, Chernogolovka, Moscow Region, 142432
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