Modification of Automatic Synthesis of [ 18 F]Fluoromisonidazole on a GE TracerLAB Fx F-N Synthesis Module

D. O. Antuganov; D. V. Ryzhkova; T. A. Zykova; V. V. Timofeev; Yu. O. Antuganova; K. Yu. Timofeeva; O. P. Samburov; M. P. Zykov

doi:10.1134/S1066362218010083

Modification of Automatic Synthesis of [¹⁸F]Fluoromisonidazole on a GE TracerLAB Fx F-N Synthesis Module

作者: Antuganov D.O.¹, Ryzhkova D.V.¹, Zykova T.A.¹, Timofeev V.V.¹, Antuganova Y.O.¹, Timofeeva K.Y.¹, Samburov O.P.¹, Zykov M.P.¹
隶属关系:
1. Almazov Northwest Federal Medical Research Center
期: 卷 60, 编号 1 (2018)
页面: 45-50
栏目: Article
URL: https://ogarev-online.ru/1066-3622/article/view/224343
DOI: https://doi.org/10.1134/S1066362218010083
ID: 224343

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详细

A procedure for preparing 1-(2-hydroxy-3-[¹⁸F]fluoropropyl)-2-nitroimidazole ([¹⁸F]fluoromisonidazole, [¹⁸F]FMISO) on a commercially available GE TracerLAB Fx F-N synthesis module was developed. The product obtained meets all the requirements of the European Pharmacopoeia (8th ed.) for clinical use. Its decay-corrected radiochemical yield is 59 ± 4% (n = 5).