Modification of Automatic Synthesis of [18F]Fluoromisonidazole on a GE TracerLAB Fx F-N Synthesis Module

Abstract

A procedure for preparing 1-(2-hydroxy-3-[¹⁸F]fluoropropyl)-2-nitroimidazole ([¹⁸F]fluoromisonidazole, [¹⁸F]FMISO) on a commercially available GE TracerLAB Fx F-N synthesis module was developed. The product obtained meets all the requirements of the European Pharmacopoeia (8th ed.) for clinical use. Its decay-corrected radiochemical yield is 59 ± 4% (n = 5).