99 m  Tc-Oxiracetam as a Potential Agent for Diagnostic Imaging of Brain: Labeling, Characterization, and Biological Evaluation

M. H. Sanad; Kh. M. Sallam; D. H. Salama

doi:10.1134/S1066362218010101

^99mTc-Oxiracetam as a Potential Agent for Diagnostic Imaging of Brain: Labeling, Characterization, and Biological Evaluation

Авторы: Sanad M.H.¹, Sallam K.M.¹, Salama D.H.²
Учреждения:
1. Labeled Compounds Department, Hot Laboratories Center
2. Health Radiation Research Department (Radiodiagnosis Unit), National Center for Radiation Research and Technology
Выпуск: Том 60, № 1 (2018)
Страницы: 58-63
Раздел: Article
URL: https://ogarev-online.ru/1066-3622/article/view/224355
DOI: https://doi.org/10.1134/S1066362218010101
ID: 224355

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Аннотация

Oxiracetam was labeled with ^99mTc using sodium dithionite (Na₂S₂O₄) as a reducing agent. The influence exerted on the labeling yield by the amounts of the reducing agent and substrate, pH, temperature, and reaction time was studied to optimize the labeling process. Biodistribution studies show that the ^99mTcoxiracetam complex is suitable as a highly selective tracer for brain imaging.