99mTc-Oxiracetam as a Potential Agent for Diagnostic Imaging of Brain: Labeling, Characterization, and Biological Evaluation
- Autores: Sanad M.H.1, Sallam K.M.1, Salama D.H.2
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Afiliações:
- Labeled Compounds Department, Hot Laboratories Center
- Health Radiation Research Department (Radiodiagnosis Unit), National Center for Radiation Research and Technology
- Edição: Volume 60, Nº 1 (2018)
- Páginas: 58-63
- Seção: Article
- URL: https://ogarev-online.ru/1066-3622/article/view/224355
- DOI: https://doi.org/10.1134/S1066362218010101
- ID: 224355
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Resumo
Oxiracetam was labeled with 99mTc using sodium dithionite (Na2S2O4) as a reducing agent. The influence exerted on the labeling yield by the amounts of the reducing agent and substrate, pH, temperature, and reaction time was studied to optimize the labeling process. Biodistribution studies show that the 99mTcoxiracetam complex is suitable as a highly selective tracer for brain imaging.
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Sobre autores
M. Sanad
Labeled Compounds Department, Hot Laboratories Center
Autor responsável pela correspondência
Email: drsanad74@gmail.com
Egito, Cairo
Kh. Sallam
Labeled Compounds Department, Hot Laboratories Center
Email: drsanad74@gmail.com
Egito, Cairo
D. Salama
Health Radiation Research Department (Radiodiagnosis Unit), National Center for Radiation Research and Technology
Email: drsanad74@gmail.com
Egito, Cairo
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