99mTc-Oxiracetam as a Potential Agent for Diagnostic Imaging of Brain: Labeling, Characterization, and Biological Evaluation


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Resumo

Oxiracetam was labeled with 99mTc using sodium dithionite (Na2S2O4) as a reducing agent. The influence exerted on the labeling yield by the amounts of the reducing agent and substrate, pH, temperature, and reaction time was studied to optimize the labeling process. Biodistribution studies show that the 99mTcoxiracetam complex is suitable as a highly selective tracer for brain imaging.

Sobre autores

M. Sanad

Labeled Compounds Department, Hot Laboratories Center

Autor responsável pela correspondência
Email: drsanad74@gmail.com
Egito, Cairo

Kh. Sallam

Labeled Compounds Department, Hot Laboratories Center

Email: drsanad74@gmail.com
Egito, Cairo

D. Salama

Health Radiation Research Department (Radiodiagnosis Unit), National Center for Radiation Research and Technology

Email: drsanad74@gmail.com
Egito, Cairo

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