Отправить статью по E-mail Preparation of 188Re-Labetalol as a β1-Adrenoceptor for Use in Nuclear Medicine
- Авторы: Marzook F.A.1, Ramadan H.E.2, Talaat H.M.1
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Учреждения:
- Labeled Compounds Department, Hot Laboratories Center
- Radioactive Isotopes and Generator Department, Hot Laboratories Center
- Выпуск: Том 61, № 2 (2019)
- Страницы: 238-243
- Раздел: Article
- URL: https://ogarev-online.ru/1066-3622/article/view/225110
- DOI: https://doi.org/10.1134/S1066362219020188
- ID: 225110
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Аннотация
Labetalol was labeled with 188Re. The reaction conditions (amounts of stannous chloride and substrate, pH, time) were optimized, and the radiochemical yield as high as 95 ± 0.4% was reached. Biodistribution in mice was studied. 188Re-Labetalol showed excellent initial heart uptake and good retention. The heart/liver ratios were 5.16, 2.70, and 2.15 at 30, 60, and 120 min post injection, respectively.
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Об авторах
F. Marzook
Labeled Compounds Department, Hot Laboratories Center
Автор, ответственный за переписку.
Email: fawzymarzouk@yahoo.com
Египет, Cairo
H. Ramadan
Radioactive Isotopes and Generator Department, Hot Laboratories Center
Email: fawzymarzouk@yahoo.com
Египет, Cairo
H. Talaat
Labeled Compounds Department, Hot Laboratories Center
Email: fawzymarzouk@yahoo.com
Египет, Cairo
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