IN HIV-INFECTED PATIENTS, DISCRORDANT RESPONSE OF CD4+ T-CELLS TO ANTIRETROVIRAL THERAPY IS ASSOCIATED WITH ENERGY METABOLISM VIOLATION
- 作者: Saidakova E.V.1, Shmagel K.V.1, Korolevskaya L.B.1, Shmagel N.G.1
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隶属关系:
- Institute of Ecology and Genetics of Microorganisms UB RAS
- 期: 卷 22, 编号 2-1 (2019)
- 页面: 515-517
- 栏目: ORIGINAL ARTICLES
- URL: https://ogarev-online.ru/1028-7221/article/view/120287
- DOI: https://doi.org/10.31857/S102872210006949-8
- ID: 120287
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全文:
详细
We evaluated the ability of memory CD4+ T-cells that were isolated from the blood of HIV-infected subjects with a discordant response to antiretroviral therapy to proliferate. It was shown that in those patients, frequency of dividing CD4+CD45RA– T-cells was increased against the background of CD4+ T-cell deficiency. However, those lymphocytes were not able to complete the cell cycle and productively divide. Furthermore, in cycling memory CD4+ T-cells violation of mitochondria and energy metabolism were detected.
作者简介
E. Saidakova
Institute of Ecology and Genetics of Microorganisms UB RAS
编辑信件的主要联系方式.
Email: radimira@list.ru
PhD, junior research scientist,
Perm
俄罗斯联邦K. Shmagel
Institute of Ecology and Genetics of Microorganisms UB RAS
Email: fake@neicon.ru
PhD, head of the department,
Perm
俄罗斯联邦L. Korolevskaya
Institute of Ecology and Genetics of Microorganisms UB RAS
Email: fake@neicon.ru
PhD, research scientist,
Perm
俄罗斯联邦N. Shmagel
Institute of Ecology and Genetics of Microorganisms UB RAS
Email: fake@neicon.ru
PhD, senior research scientist,
Perm
俄罗斯联邦参考
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- Tchao N. K., Turka L. A. Lymphodepletion and homeostatic proliferation: implications for transplantation. Am J Transplant. 2012, 12, 1079–1090.
- Younes S. A., Talla A., Pereira Ribeiro S., Saidakova E. V., Korolevskaya L. B., Shmagel K. V., Shive C. L., Freeman M. L., Panigrahi S., Zweig S., Balderas R., Margolis L., Douek D. C., Anthony D. D., Pandiyan P., Cameron M., Sieg S. F., Calabrese L. H., Rodriguez B., Lederman M. M. Cycling CD4+ T cells in HIV-infected immune nonresponders have mitochondrial dysfunction. J Clin Invest. 2018, 128, 5083–5094.
- Battersby B. J., Richter U. Why translation counts for mitochondria – retrograde signalling links mitochondrial protein synthesis to mitochondrial biogenesis and cell proliferation. J Cell Sci. 2013, 126, 4331–4338.
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