IN HIV-INFECTED PATIENTS, DISCRORDANT RESPONSE OF CD4+ T-CELLS TO ANTIRETROVIRAL THERAPY IS ASSOCIATED WITH ENERGY METABOLISM VIOLATION
- Authors: Saidakova E.V.1, Shmagel K.V.1, Korolevskaya L.B.1, Shmagel N.G.1
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Affiliations:
- Institute of Ecology and Genetics of Microorganisms UB RAS
- Issue: Vol 22, No 2-1 (2019)
- Pages: 515-517
- Section: ORIGINAL ARTICLES
- URL: https://ogarev-online.ru/1028-7221/article/view/120287
- DOI: https://doi.org/10.31857/S102872210006949-8
- ID: 120287
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Abstract
We evaluated the ability of memory CD4+ T-cells that were isolated from the blood of HIV-infected subjects with a discordant response to antiretroviral therapy to proliferate. It was shown that in those patients, frequency of dividing CD4+CD45RA– T-cells was increased against the background of CD4+ T-cell deficiency. However, those lymphocytes were not able to complete the cell cycle and productively divide. Furthermore, in cycling memory CD4+ T-cells violation of mitochondria and energy metabolism were detected.
About the authors
E. V. Saidakova
Institute of Ecology and Genetics of Microorganisms UB RAS
Author for correspondence.
Email: radimira@list.ru
PhD, junior research scientist,
Perm
Russian FederationK. V. Shmagel
Institute of Ecology and Genetics of Microorganisms UB RAS
PhD, head of the department,
Perm
Russian FederationL. B. Korolevskaya
Institute of Ecology and Genetics of Microorganisms UB RAS
PhD, research scientist,
Perm
Russian FederationN. G. Shmagel
Institute of Ecology and Genetics of Microorganisms UB RAS
PhD, senior research scientist,
Perm
Russian FederationReferences
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