IN HIV-INFECTED PATIENTS, DISCRORDANT RESPONSE OF CD4+ T-CELLS TO ANTIRETROVIRAL THERAPY IS ASSOCIATED WITH ENERGY METABOLISM VIOLATION
- Authors: Saidakova E.V.1, Shmagel K.V.1, Korolevskaya L.B.1, Shmagel N.G.1
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Affiliations:
- Institute of Ecology and Genetics of Microorganisms UB RAS
- Issue: Vol 22, No 2-1 (2019)
- Pages: 515-517
- Section: ORIGINAL ARTICLES
- URL: https://ogarev-online.ru/1028-7221/article/view/120287
- DOI: https://doi.org/10.31857/S102872210006949-8
- ID: 120287
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Abstract
We evaluated the ability of memory CD4+ T-cells that were isolated from the blood of HIV-infected subjects with a discordant response to antiretroviral therapy to proliferate. It was shown that in those patients, frequency of dividing CD4+CD45RA– T-cells was increased against the background of CD4+ T-cell deficiency. However, those lymphocytes were not able to complete the cell cycle and productively divide. Furthermore, in cycling memory CD4+ T-cells violation of mitochondria and energy metabolism were detected.
About the authors
E. V. Saidakova
Institute of Ecology and Genetics of Microorganisms UB RAS
Author for correspondence.
Email: radimira@list.ru
PhD, junior research scientist,
Perm
Russian FederationK. V. Shmagel
Institute of Ecology and Genetics of Microorganisms UB RAS
Email: fake@neicon.ru
PhD, head of the department,
Perm
Russian FederationL. B. Korolevskaya
Institute of Ecology and Genetics of Microorganisms UB RAS
Email: fake@neicon.ru
PhD, research scientist,
Perm
Russian FederationN. G. Shmagel
Institute of Ecology and Genetics of Microorganisms UB RAS
Email: fake@neicon.ru
PhD, senior research scientist,
Perm
Russian FederationReferences
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