Prediction of the risk of developing pulmonary tuberculosis in patients with comorbid pathology of the gastrointestinal tract

Gastrointestinal tract (GIT) diseases are widespread among the population, including rural residents. Long-term course without sufficient therapy can lead to protein-energy and immunological deficiency, making patients vulnerable to tuberculosis infection.

Objective. To predict the risk of developing pulmonary tuberculosis (TB) in patients with comorbid gastrointestinal pathology living in rural areas.

Materials and methods. The retrospective study included 268 patients with newly diagnosed TB. In 48 cases, a combination of TB and chronic gastrointestinal diseases was observed. The odds ratio (OR) was used as a tool to determine the risk of developing TB. The factor analysis method was used to determine the temple factors.

Results. The odds ratio (OR), which tells the odds of an event occurring in one group to the odds of an event occurring in another group, was used to determine the risk of developing TB: OR=10.63 (CI: 7.75–14.58; p<0.001). In the presence of chronic gastritis – OR=7.03 (CI: 4.87–10.15; p<0.001), peptic ulcer disease – OR=112.81 (CI: 61.66–206.42; p<0.001). According to the results of factor analysis, the risk group for developing TB included rural residents, elderly, suffering from peptic ulcer disease, having bad habits (smoking), living in unfavorable conditions with stove heating. TB was detected when they sought medical help with complaints from the bronchopulmonary system.