N4-(ω-Aminoalkyl)- and N4-(ω-Dansylaminoalkyl)-5-methyl-2'-deoxycytidines

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Resumo

New derivatives of N4-(dodecyl)-5-methyl-2'-deoxycytidine containing terminal amino groups at the end of an alkyl linker have been synthesized. It is shown that they are convenient syntones for the subsequent introduction of dansyl fluorophore groups. One of the N4-ω-dansylaminoalkyl derivatives has showed moderate antibacterial activity against the Mycobacterium smegmatis strain. This derivative can be used to study the subcellular localization of this kind of compounds.

Sobre autores

D. Makarov

Engelhardt Institute of Molecular Biology Russian Academy of Sciences

Email: dmitmakarov_97@mail.ru
Moscow, Russia

M. Jasko

Engelhardt Institute of Molecular Biology Russian Academy of Sciences

Moscow, Russia

I. Karpenko

Engelhardt Institute of Molecular Biology Russian Academy of Sciences

Moscow, Russia

Y. Tkachev

Engelhardt Institute of Molecular Biology Russian Academy of Sciences

Moscow, Russia

B. Vasilyeva

Gause Institute of New Antibiotics

Moscow, Russia

O. Efremenkova

Gause Institute of New Antibiotics

Moscow, Russia

S. Kochetkov

Engelhardt Institute of Molecular Biology Russian Academy of Sciences

Moscow, Russia

L. Alexandrova

Engelhardt Institute of Molecular Biology Russian Academy of Sciences

Moscow, Russia

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