Enzymatic Synthesis and Molecular Docking Studies of Substituted 5-Phenyl-1,2,4-triazole-3-thione Deoxyribosides
- Authors: Fateev I.V1, Sasmakov S.A2, Ziyaev A.A2, Abdurakhmanov J.M2, Toshmurodov T.T2, Ikramov S.A2, Tosheva N.A2, Frolova V.D1, Zorina E.A1, Zayats E.A1, Eletskaya B.Z1, Smirnova O.S1, Berzina M.Y1, Arnautova A.O1, Abramchik Y.A1, Kostromina M.A1, Kayushin A.L1, Antonov K.V1, Prokhorenko I.A1, Paramonov A.S1, Andronova V.L3, Esipov R.S1, Azimova S.S2, Miroshnikov A.I1, Konstantinova I.D1
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Affiliations:
- Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Acad. S.Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan
- D. I. Ivanovsky Institute of Virology (N. F. Gamaleya Research Center of Epidemiology and Microbiology, Ministry of Healthcare of the Russian Federation)
- Issue: Vol 51, No 4 (2025)
- Pages: 706-714
- Section: Articles
- URL: https://ogarev-online.ru/0132-3423/article/view/309121
- DOI: https://doi.org/10.31857/S0132342325040149
- EDN: https://elibrary.ru/LOEDUZ
- ID: 309121
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Abstract
About the authors
I. V Fateev
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: ifateev@gmail.com
Moscow, Russia
S. A Sasmakov
Acad. S.Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan
Email: sasmakov@web.de
Tashkent, Uzbekistan
A. A Ziyaev
Acad. S.Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of UzbekistanTashkent, Uzbekistan
J. M Abdurakhmanov
Acad. S.Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of UzbekistanTashkent, Uzbekistan
T. T Toshmurodov
Acad. S.Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of UzbekistanTashkent, Uzbekistan
S. A Ikramov
Acad. S.Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of UzbekistanTashkent, Uzbekistan
N. A Tosheva
Acad. S.Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of UzbekistanTashkent, Uzbekistan
V. D Frolova
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of SciencesMoscow, Russia
E. A Zorina
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of SciencesMoscow, Russia
E. A Zayats
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of SciencesMoscow, Russia
B. Z Eletskaya
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of SciencesMoscow, Russia
O. S Smirnova
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of SciencesMoscow, Russia
M. Y Berzina
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of SciencesMoscow, Russia
A. O Arnautova
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of SciencesMoscow, Russia
Y. A Abramchik
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of SciencesMoscow, Russia
M. A Kostromina
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of SciencesMoscow, Russia
A. L Kayushin
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of SciencesMoscow, Russia
K. V Antonov
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of SciencesMoscow, Russia
I. A Prokhorenko
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of SciencesMoscow, Russia
A. S Paramonov
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of SciencesMoscow, Russia
V. L Andronova
D. I. Ivanovsky Institute of Virology (N. F. Gamaleya Research Center of Epidemiology and Microbiology, Ministry of Healthcare of the Russian Federation)Moscow, Russia
R. S Esipov
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of SciencesMoscow, Russia
Sh. S Azimova
Acad. S.Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of UzbekistanTashkent, Uzbekistan
A. I Miroshnikov
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of SciencesMoscow, Russia
I. D Konstantinova
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of SciencesMoscow, Russia
References
- Couto Rodrigues S., Silva Moratório de Moraes R., T avares de Almeida Pinto G., Miranda Martins M.T., Antunes do Nascimento P., Alves Soares D.L., Mestre Botelho A.B., Cardoso Cruz C., Cunha A.C. // Chem. Rec. 2025. V. 25. P. e202400190. https://doi.org/10.1002/tcr.202400190
- Ghous F. Shukla S., Parveen S., Kumar S., Banerjee M., Bishnoi A. // J. Mol. Struct. 2024. V. 1304. P. 137578. https://doi.org/10.1016/j.molstruc.2024.137578
- Zhou C.H., Wang Y. // Curr. Med. Chem. 2012. V. 19. P. 239–280. https://doi.org/10.2174/092986712803414213
- Siddiqui S.Z., Arfan M., Abbasi M.A., Shah S.A.A., Ashraf M., Hussain S., Saleem R.Sh.Z., Rafique R., Khan Kh.M. // ChemistrySelect. 2020. V. 5. P. 6430– 6439. https://doi.org/10.1002/slct.201904905
- Khan I., Khan A., Halim S.A., Saeed A., Mehsud S., Csuk R., Ibrar A. // Int. J. Biol. Macromol. 2020. V. 142. P. 345–354. https://doi.org/10.1016/j. ijbiomac.2019.09.105
- Roman G., Bostanaru A.C., Nastasa V., Mares M // Turk. J. Chem. 2019. V. 43. P. 531–546. https://doi.org/10.3906/kim-1811-4
- Kumar S., Khokra S.L., Yadav A. // Future J. Pharm. Sci. 2021. V. 7. P. 106. https://doi.org/10.1186/s43094-021-00241-3
- Zahoor A.F., Saeed S., Rasul A., Noreen R., Irfan A., Ahmad S., Zaki M.E. // Biomedicines. 2023. V. 11. P. 3078. https://doi.org/10.3390/biomedicines11113078
- Ziyaev A., Sasmakov S., Okmanov R., Makhmudov U., Toshmurodov T., Ziyaeva М., Tosheva N., Azimova Sh. // Chem. Data Collections. 2025. V. 56. P. 101182. https://doi.org/10.1016/j.cdc.2025.101182
- Küçükgüzel S.G., Çıkla-Süzgün P. // Eur. J. Med. Chem. 2015. V. 97. P. 830–870. https://doi.org/10.1016/j.ejmech.2014.11.033
- Fateev I.V., Sasmakov S.A., Abdurakhmanov J.M., Ziyaev A.A., Khasanov S.S., Eshboev F.B., Ashirov O.N., Frolova V.D., Eletskaya B.Z., Smirnova O.S., Berzina M.Y., Arnautova A.O., Abramchik Y.A., Kostromina M.A., Kayushin A.L., Antonov K.V., Paramonov A.S., Andronova V.L., Galegov G.A., Esipov R.S., Azimova S.S., Miroshnikov A.I., Konstantinova I.D. // Biomolecules. 2024. V. 14. P. 745. https://doi.org/10.3390/biom14070745
- Timofeev V.I., Zhukhlistova N.E., Abramchik Y.A., Fateev I.V., Kostromina M.A., Muravieva T.I., Esipov R.S., Kuranova I.P. // J. Acta Crystallogr. F Struct. Biol. Commun. 2018. V. 74. P. 355–362. https://doi.org/10.1107/S2053230X18006337
- Koellner G., Luić M., Shugar D., Saenger W., Bzowska A. // J. Mol. Biol. 1998. V. 280. P. 153–166. https://doi.org/10.1006/jmbi.1998.1799
- Esipov R.S., Gurevich A.I., Chuvikovsky D.V., Chupova L.A., Muravyova T.I., Miroshnikov A.I. // Protein Expr Purif. 2002. V. 24. P. 56–60. https://doi.org/10.1006/prep.2001.1524
- Bugnon M., Röhrig U.F., Goullieux M., Perez M.A.S., Daina A., Michielin O., Zoete V. // Nucleic Acids Res. 2024. V. 52. P. W324-W332. https://doi.org/10.1093/nar/gkae300
- Röhrig U.F., Goullieux M., Bugnon M., Zoete V. // J. Chem. Inf. Model. 2023. V. 63. P. 3925–3940. https://doi.org/10.1021/acs.jcim.3c00054
- Pettersen E.F., Goddard T.D., Huang C.C., Couch G.S., Greenblatt D.M., Meng E.C., Ferrin T.E. // J. Comput. Chem. 2004. V. 25. P. 1605-1612. https://doi.org/10.1002/jcc.20084
- Andronova V.L., Galegov G.A., Ias’ko M.V., Kukhanova M.K., IuS S. // Vopr. Virusol. 2010. V. 55. P. 31–34.
- Gus’kova A.A., Skoblov M.Y., Korovina A.N., Yasko M.V., Karpenko I.L., Kukhanova M.K., Andronova V.L., Galegov G.A., Skoblov Y.S. // Chem. Biol. Drug Des. 2009. V. 74. P. 382–389. https://doi.org/10.1111/j.1747-0285.2009.00874.x
- Holý A., De Clercq E., Votruba I. // Nucl. Analogues as Antiviral Agents. 1989. V 401. P. 51–71. https://doi.org/10.1021/bk-1989-0401
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